Shih-En Tseng1, Yi-You Chiou2, Yu-Chin Lee3, Reury-Perng Perng3, Whang-Peng Jacqueline4, Yuh-Min Chen5. 1. Internal Medicine Department, Zhongxing Branch, Taipei City Hospital, Taipei, Taiwan. 2. Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University, School of Medicine, Taipei, Taiwan. 3. Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University, School of Medicine, Taipei, Taiwan. 4. Center of Excellent Cancer Research, Taipei Medical University, Taipei, Taiwan. 5. Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University, School of Medicine, Taipei, Taiwan; Center of Excellent Cancer Research, Taipei Medical University, Taipei, Taiwan. Electronic address: ymchen@vghtpe.gov.tw.
Abstract
BACKGROUND: In patients with non-small cell lung cancer (NSCLC), the development of liver metastasis (LM) is a poor prognostic factor. Whether systemic treatment combined with local treatment for LM has benefit for NSCLC patients with LM is unknown. METHODS: We retrospectively reviewed and analyzed the clinical data and tumor epidermal growth factor receptor (EGFR) mutation status of 673 pulmonary adenocarcinoma patients, including 85 patients who developed LM at any time point in the course of the disease. Radiofrequency ablation (RFA) with real-time ultrasonographic guidance was used for local treatment of LM in these patients, if appropriate. RESULTS: Patients with an EGFR mutation were more prone to having synchronous LM than patients with EGFR wild-type (50.0% vs. 23.5%, P=0.019). Fifty-six patients (65.9%) had ≦5 LM nodules. The median overall survival (OS) of patients with ≦5 LM nodules was 7.6 months compared with 2.9 months for those with multiple nodules (P<0.001). The independent prognostic factors after LM were performance status, EGFR mutation, synchronous LM and LM numbers. The independent prognostic factors for patients with ≦5 LM nodules were performance status, EGFR mutation, LM concomitant with adrenal metastasis and having received RFA. Patients who received RFA treatment (n=6) had longer OS after LM than those without RFA treatment (n=42) (23.1 vs. 7.9 months, P=0.035). CONCLUSIONS: We recommend that patients with a better performance status and ≦5 LM nodules be considered for systemic treatment combined with RFA when LM develops.
BACKGROUND: In patients with non-small cell lung cancer (NSCLC), the development of liver metastasis (LM) is a poor prognostic factor. Whether systemic treatment combined with local treatment for LM has benefit for NSCLCpatients with LM is unknown. METHODS: We retrospectively reviewed and analyzed the clinical data and tumorepidermal growth factor receptor (EGFR) mutation status of 673 pulmonary adenocarcinomapatients, including 85 patients who developed LM at any time point in the course of the disease. Radiofrequency ablation (RFA) with real-time ultrasonographic guidance was used for local treatment of LM in these patients, if appropriate. RESULTS:Patients with an EGFR mutation were more prone to having synchronous LM than patients with EGFR wild-type (50.0% vs. 23.5%, P=0.019). Fifty-six patients (65.9%) had ≦5 LM nodules. The median overall survival (OS) of patients with ≦5 LM nodules was 7.6 months compared with 2.9 months for those with multiple nodules (P<0.001). The independent prognostic factors after LM were performance status, EGFR mutation, synchronous LM and LM numbers. The independent prognostic factors for patients with ≦5 LM nodules were performance status, EGFR mutation, LM concomitant with adrenal metastasis and having received RFA. Patients who received RFA treatment (n=6) had longer OS after LM than those without RFA treatment (n=42) (23.1 vs. 7.9 months, P=0.035). CONCLUSIONS: We recommend that patients with a better performance status and ≦5 LM nodules be considered for systemic treatment combined with RFA when LM develops.
Authors: Britta Weber; Mitchell Liu; Paul Sobkin; Stephan W Morris; David Hout; Nicholas van der Westhuizen; R Petter Tonseth; David L Saltman Journal: J Med Radiat Sci Date: 2015-10-03