| Literature DB >> 25240269 |
Hajime Kanamori1, Risako Kakuta2, Hisakazu Yano3, Tomoyuki Suzuki4, Yoshiaki Gu3, Chihiro Oe3, Shinya Inomata3, Tetsuji Aoyagi3, Masumitsu Hatta3, Shiro Endo3, Koichi Tokuda3, David J Weber5, Yasuhiro Nakamura6, Yoshikatsu Saiki4, Mitsuo Kaku3.
Abstract
Culture-negative endocarditis remains a diagnostic and therapeutic challenge despite recent medical advances. Streptococcus tigurinus, a novel member of the Streptococcus mitis group, was first identified in Zurich. S. tigurinus possesses virulence determinants and causes invasive infections. We report a case of culture-negative endocarditis with serious complications due to S. tigurinus, which was identified by 16S ribosomal RNA gene sequence analysis of excised valve tissue specimens. This technique is useful for identification of the causative microorganism in patients with culture-negative endocarditis and may facilitate early diagnosis and appropriate antimicrobial treatment.Entities:
Keywords: 16S ribosomal RNA gene analysis; Culture-negative endocarditis; Endocarditis; Streptococcus; Streptococcus tigurinus
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Year: 2014 PMID： 25240269 DOI： 10.1016/j.jiac.2014.08.014
Source DB: PubMed Journal: J Infect Chemother ISSN： 1341-321X Impact factor: 2.211