Literature DB >> 2524025

Nucleotide sequence and structural organization of the human FMS proto-oncogene.

A Hampe1, B M Shamoon, M Gobet, C J Sherr, F Galibert.   

Abstract

The human proto-oncogene c-fms [FMS] on chromosome 5q33.3 encodes a transmembrane glycoprotein with tyrosine kinase activity that functions as the cell surface receptor for the macrophage colony stimulating factor (CSF-1 or M-CSF). Overlapping bacteriophage clones that included 35 kb of the FMS locus and contained the complete coding sequence of the CSF-1 receptor were subjected to nucleotide sequencing analysis. Comparison with the cDNA sequence of the human c-fms gene indicated that at least one 5' noncoding exon is located far upstream (ca. 26 kb) from sequences encoding the CSF-1 receptor. The FMS coding sequence consists of 21 small exons and heterogeneously sized introns, ranging from 6.3 kb to less than 0.1 kb in complexity.

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Year:  1989        PMID： 2524025

Source DB:  PubMed          Journal:  Oncogene Res        ISSN： 0890-6467


  12 in total

1.  A frequent EcoRI RFLP demonstrated within the human M-CSF receptor gene (CSFIR).

Authors:  J Felgner; H Kreipe; K Jaquet; K Heidorn; F Zschunke; R Heuss; H J Radzun; M R Parwaresch
Journal:  Nucleic Acids Res       Date:  1991-09-25       Impact factor: 16.971

2.  Dinucleotide repeat polymorphism at the human c-fms protooncogene for the CFS-1 receptor (CFS1R).

Authors:  M H Polymeropoulos; H Xiao; D S Rath; C R Merril
Journal:  Nucleic Acids Res       Date:  1991-03-11       Impact factor: 16.971

3.  Genomic organization of the extracellular coding region of the human FGFR4 and FLT4 genes: evolution of the genes encoding receptor tyrosine kinases with immunoglobulin-like domains.

Authors:  F Agnès; M M Toux; C André; F Galibert
Journal:  J Mol Evol       Date:  1997-07       Impact factor: 2.395

4.  Variation in short tandem repeat sequences--a survey of twelve microsatellite loci for use as forensic identification markers.

Authors:  A Urquhart; C P Kimpton; T J Downes; P Gill
Journal:  Int J Legal Med       Date:  1994       Impact factor: 2.686

5.  Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events.

Authors:  Kevin Wilhelmsen; Peter van der Geer
Journal:  Mol Cell Biol       Date:  2004-01       Impact factor: 4.272

6.  A GM-colony-stimulating factor (CSF) activated ribonuclease system transregulates M-CSF receptor expression in the murine FDC-P1/MAC myeloid cell line.

Authors:  B C Gliniak; L S Park; L R Rohrschneider
Journal:  Mol Biol Cell       Date:  1992-05       Impact factor: 4.138

7.  Human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene.

Authors:  R A Fleischman
Journal:  J Clin Invest       Date:  1992-06       Impact factor: 14.808

8.  A colony-stimulating factor 1 (CSF-1) receptor/platelet-derived growth factor-beta receptor gene fusion confers CSF-1 independence and tumorigenicity on a c-myc-immortalized monocyte cell line.

Authors:  M R Eccles; F J King; M D Cole
Journal:  Mol Cell Biol       Date:  1992-01       Impact factor: 4.272

Review 9.  CSF-1 receptor signaling in myeloid cells.

Authors:  E Richard Stanley; Violeta Chitu
Journal:  Cold Spring Harb Perspect Biol       Date:  2014-06-02       Impact factor: 10.005

10.  Gene expression of inflammatory molecules in circulating lymphocytes from arsenic-exposed human subjects.

Authors:  Meei-Maan Wu; Hung-Yi Chiou; I-Ching Ho; Chien-Jen Chen; Te-Chang Lee
Journal:  Environ Health Perspect       Date:  2003-08       Impact factor: 9.031
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