Literature DB >> 25240195

Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker.

Zhi-Yong Tan1, Birgit T Priest2, Jeffrey L Krajewski2, Kelly L Knopp2, Eric S Nisenbaum2, Theodore R Cummins3.   

Abstract

Resurgent sodium currents likely play a role in modulating neuronal excitability. Here we studied whether protein kinase C (PKC) activation can increase resurgent currents produced by the human sodium channel hNav1.7. We found that a PKC agonist significantly enhanced hNav1.7-mediated resurgent currents and this was prevented by PKC antagonists. The enhancing effects were replicated by two phosphorylation-mimicking mutations and were prevented by a phosphorylation-deficient mutation at a conserved PKC phosphorylation site (Serine 1479). Our results suggest that PKC can increase sodium resurgent currents through phosphorylation of a conserved Serine residue located in the domain III-IV linker of sodium channels.
Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Mutation; Protein kinase C; Resurgent current; Sodium channel; Voltage clamp; hNav1.7

Mesh：

Substances：

Year:  2014        PMID： 25240195      PMCID： PMC4451938          DOI： 10.1016/j.febslet.2014.09.011

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  28 in total

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Authors:  Zhi-Yong Tan; Andrew D Piekarz; Birgit T Priest; Kelly L Knopp; Jeffrey L Krajewski; Jeff S McDermott; Eric S Nisenbaum; Theodore R Cummins
Journal:  J Neurosci       Date:  2014-05-21       Impact factor: 6.167

4.  Chelerythrine is a potent and specific inhibitor of protein kinase C.

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Journal:  Biochem Biophys Res Commun       Date:  1990-11-15       Impact factor: 3.575

5.  A role for phosphorylation in the maintenance of resurgent sodium current in cerebellar purkinje neurons.

Authors:  Tina M Grieco; Fatemeh S Afshari; Indira M Raman
Journal:  J Neurosci       Date:  2002-04-15       Impact factor: 6.167

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Authors:  Ruth Sittl; Angelika Lampert; Tobias Huth; E Theresa Schuy; Andrea S Link; Johannes Fleckenstein; Christian Alzheimer; Peter Grafe; Richard W Carr
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-09       Impact factor: 11.205

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Journal:  Front Biosci       Date:  2004-05-01

8.  The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

Authors:  D Toullec; P Pianetti; H Coste; P Bellevergue; T Grand-Perret; M Ajakane; V Baudet; P Boissin; E Boursier; F Loriolle
Journal:  J Biol Chem       Date:  1991-08-25       Impact factor: 5.157

9.  Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons.

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Authors:  Amanda H Lewis; Indira M Raman
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  10 in total

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Authors:  Agnes S Zybura; Anthony J Baucum; Anthony M Rush; Theodore R Cummins; Andy Hudmon
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Review 2.  PKC regulation of ion channels: The involvement of PIP2.

Authors:  Kirin D Gada; Diomedes E Logothetis
Journal:  J Biol Chem       Date:  2022-05-16       Impact factor: 5.486

3.  Antihyperalgesic effect of tetrodotoxin in rat models of persistent muscle pain.

Authors:  P Alvarez; J D Levine
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4.  Nociceptor Overexpression of NaV1.7 Contributes to Chronic Muscle Pain Induced by Early-Life Stress.

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5.  BDNF-TrkB Signaling Coupled to nPKCε and cPKCβI Modulate the Phosphorylation of the Exocytotic Protein Munc18-1 During Synaptic Activity at the Neuromuscular Junction.

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Journal:  Front Mol Neurosci       Date:  2018-06-12       Impact factor: 5.639

6.  Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner.

Authors:  Yangyang Li; Tengteng Zhu; Huan Yang; Sulayman D Dib-Hajj; Stephen G Waxman; Ye Yu; Tian-Le Xu; Xiaoyang Cheng
Journal:  Mol Pain       Date:  2018-05-23       Impact factor: 3.395

7.  Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons.

Authors:  Cindy Barbosa; Zhi-Yong Tan; Ruizhong Wang; Wenrui Xie; Judith A Strong; Reesha R Patel; Michael R Vasko; Jun-Ming Zhang; Theodore R Cummins
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Review 8.  Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes.

Authors:  Cedric J Laedermann; Hugues Abriel; Isabelle Decosterd
Journal:  Front Pharmacol       Date:  2015-11-05       Impact factor: 5.810

9.  Biphasic voltage-dependent inactivation of human NaV 1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin-secreting cells.

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10.  Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway.

Authors:  Federico Scala; Miroslav N Nenov; Elizabeth J Crofton; Aditya K Singh; Oluwarotimi Folorunso; Yafang Zhang; Brent C Chesson; Norelle C Wildburger; Thomas F James; Musaad A Alshammari; Tahani K Alshammari; Hannah Elfrink; Claudio Grassi; James M Kasper; Ashley E Smith; Jonathan D Hommel; Cheryl F Lichti; Jai S Rudra; Marcello D'Ascenzo; Thomas A Green; Fernanda Laezza
Journal:  Cell Rep       Date:  2018-04-10       Impact factor: 9.423
  10 in total

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