Maria Kompoti1, Martha Michalia2, Vaia Salma2, Evangelia Diogou2, Anthi Lakoumenta3, Phyllis-Maria Clouva-Molyvdas2. 1. Intensive Care Unit, Thriassio General Hospital of Eleusis, Athens, Greece. Electronic address: mariakompoti@gmail.com. 2. Intensive Care Unit, Thriassio General Hospital of Eleusis, Athens, Greece. 3. Department of Laboratory Hematology, Thriassio General Hospital of Eleusis, Athens, Greece.
Abstract
OBJECTIVE: This study investigated the clinical significance of HbA1c levels on admission in the intensive care unit (ICU) as a prognostic marker for morbidity and mortality in critically ill patients. PATIENTS- METHODS: This prospective observational study included consecutive patients admitted in an 8-bed multidisciplinary ICU. Patients were prospectively followed from ICU admission until ICU outcome (death/discharge). All patients had an HbA1c measurement upon admission in the ICU. RESULTS: Five hundred fifty-five consecutive patients (376 males, 179 females) were included in the study. In patients without prior diabetes mellitus (DM) diagnosis, a cutoff of 6.5% for HbA1c (diagnostic cutoff for DM) predicted more severe disease (as described by Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores at admission) and higher ICU mortality (adjusted odds ratio, 2.33; 95% confidence interval, 1.04-5.25). In the subgroup of patients with a history of DM, a cutoff of 7% for HbA1c (glycemic target) had no predicting ability for ICU mortality. CONCLUSIONS: HbA1c is a useful tool for the diagnosis of a previously undiagnosed DM. This study showed that in critically ill patients with previously undiagnosed DM, HbA1c at admission is significantly associated with ICU mortality.
OBJECTIVE: This study investigated the clinical significance of HbA1c levels on admission in the intensive care unit (ICU) as a prognostic marker for morbidity and mortality in critically illpatients. PATIENTS- METHODS: This prospective observational study included consecutive patients admitted in an 8-bed multidisciplinary ICU. Patients were prospectively followed from ICU admission until ICU outcome (death/discharge). All patients had an HbA1c measurement upon admission in the ICU. RESULTS: Five hundred fifty-five consecutive patients (376 males, 179 females) were included in the study. In patients without prior diabetes mellitus (DM) diagnosis, a cutoff of 6.5% for HbA1c (diagnostic cutoff for DM) predicted more severe disease (as described by Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores at admission) and higher ICU mortality (adjusted odds ratio, 2.33; 95% confidence interval, 1.04-5.25). In the subgroup of patients with a history of DM, a cutoff of 7% for HbA1c (glycemic target) had no predicting ability for ICU mortality. CONCLUSIONS: HbA1c is a useful tool for the diagnosis of a previously undiagnosed DM. This study showed that in critically illpatients with previously undiagnosed DM, HbA1c at admission is significantly associated with ICU mortality.
Authors: Ata Mahmoodpoor; Hadi Hamishehkar; Kamran Shadvar; Mohammadtaghi Beigmohammadi; Afshin Iranpour; Sarvin Sanaie Journal: Indian J Crit Care Med Date: 2016-02
Authors: Yasmine Ali Abdelhamid; Palash Kar; Mark E Finnis; Liza K Phillips; Mark P Plummer; Jonathan E Shaw; Michael Horowitz; Adam M Deane Journal: Crit Care Date: 2016-09-27 Impact factor: 9.097