Laura Louzao Martinez 1 , Elza Friedländer 1 , Jeroen A W M van der Laak 1 , Konnie M Hebeda 2 Show Affiliations »
Abstract
OBJECTIVES: IgG4-related disease is a recently recognized condition that can be associated with lymphadenopathy, with several histologic patterns and increased absolute number and ratio of immunoglobulin G4 (IgG4)-positive plasma cells. However, these findings are considered to be not exclusively specific for IgG4-related disease. METHODS: The occurrence of the histologic patterns reported in patients with isolated lymphadenopathy was studied and correlated with the clinical presentation to determine their predictive value for IgG4-related lymphadenopathy. RESULTS: We found cases meeting all histologic criteria for IgG4-related lymphadenopathy, without clinical signs of IgG4-related disease. The only pattern that was not seen in this series was an inflammatory pseudotumor-like picture. CONCLUSION: Without a clinical suspicion of IgG4-related disease, these morphologic patterns and high numbers of IgG4-positive plasma cells should be interpreted with care to avoid an erroneous diagnosis of IgG4-related disease. Copyright© by the American Society for Clinical Pathology.
OBJECTIVES: IgG4-related disease is a recently recognized condition that can be associated with lymphadenopathy , with several histologic patterns and increased absolute number and ratio of immunoglobulin G4 (IgG4)-positive plasma cells. However, these findings are considered to be not exclusively specific for IgG4-related disease. METHODS: The occurrence of the histologic patterns reported in patients with isolated lymphadenopathy was studied and correlated with the clinical presentation to determine their predictive value for IgG4-related lymphadenopathy . RESULTS: We found cases meeting all histologic criteria for IgG4-related lymphadenopathy , without clinical signs of IgG4-related disease. The only pattern that was not seen in this series was an inflammatory pseudotumor-like picture. CONCLUSION: Without a clinical suspicion of IgG4-related disease, these morphologic patterns and high numbers of IgG4-positive plasma cells should be interpreted with care to avoid an erroneous diagnosis of IgG4-related disease. Copyright© by the American Society for Clinical Pathology.
Entities: Disease
Species
Keywords:
IgG4; IgG4-related sclerosing disease; Lymphadenopathy
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Year: 2014
PMID： 25239412 DOI： 10.1309/AJCPX6VF6BGZVJGE
Source DB: PubMed Journal: Am J Clin Pathol ISSN： 0002-9173 Impact factor: 2.493