| Literature DB >> 2523916 |
C Agnisolo1, L Cariello, A De Santis, A Miralto, B Tota.
Abstract
The chronotropic and inotropic effects of four atrial peptides (cardiodilatin 1-16, atrial natriuretic factor 8-33 and atriopeptin I and III) on the isolated systemic heart of Octopus vulgaris were studied. Using a preparation that produces a physiological stroke volume at physiological input pressures, it was found that ANF, atriopeptin I and atriopeptin III exerted both negative chronotropic and inotropic effects. In contrast, cardiodilatin produced a positive inotropic effect. A dose-response curve of ANF is reported, showing a threshold concentration of about 10(-12) M. The pharmacological and physiological implications of these results are discussed in relation to some characteristics of the cephalopod systemic heart.Entities:
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Year: 1989 PMID： 2523916 DOI： 10.1007/bf00693001
Source DB: PubMed Journal: J Comp Physiol B ISSN： 0174-1578 Impact factor: 2.200