| Literature DB >> 25238672 |
Lucia Soliño1, Francesc X Sureda2, Jorge Diogène3.
Abstract
Marine dinoflagelates from the genus Dynophisis are important producers of Diarrhetic Shellfish Poisoning (DSP) toxins which are responsible for human intoxications. The present work is an approach to study the relative toxicity of DSP toxins effects on Neuro-2a, NG108-15 and MCF-7 cell-lines. Certified standards of okadaic acid (OA), dinophysistoxin-1 (DTX-1) and dinophysistoxin-2 (DTX-2) were used. Our results show that the three toxins exhibit similar cytotoxicity in Neuro-2a and NG108-15 cell lines. Conversely, MCF-7 cells were the least sensitive to these toxins. DTX-1 displayed the most toxic effect in the three tested cell lines.Entities:
Keywords: Cell-based assay (CBA); Dinophysistoxin-1 (DTX-1); Dinophysistoxin-2 (DTX-2); Marine toxins; Okadaic acid (OA)
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Year: 2014 PMID： 25238672 DOI： 10.1016/j.tiv.2014.09.002
Source DB: PubMed Journal: Toxicol In Vitro ISSN： 0887-2333 Impact factor: 3.500