BACKGROUND AND AIM: The role of vitamin D playing in patients with chronic hepatitis C has been intensively studied. However, studies on the potential interaction between vitamin D level and chronic hepatitis B are still limited. This study aimed to explore whether any association existed between serum vitamin D level and liver histology or virological parameters in patients with chronic hepatitis B infection in Southern China. METHODS: 25-Hydroxyvitamin D serum levels were determined in a cohort of 242 treatment-naïve chronic hepatitis B patients. Histologic assessment was based on Knodell histologic activity index and Ishak fibrosis staging. Predictors of vitamin D insufficiency were identified using multivariate analysis. RESULTS: Mean 25-hydroxyvitamin D value was 33.90 ng/mL. The percentage of patients with different concentration of 25-hydroxyvitamin D (≥ 30 ng/mL, 20-30 ng/mL, < 20 ng/mL) were 59.9%, 31.4%, and 8.7%, respectively. Gender, season, age, and viral genotype were independent predictors of vitamin D insufficiency (< 30 ng/mL). Patients with genotype B virus infection had a lower mean 25-hydroxyvitamin D level (P = 0.023) and higher prevalence of vitamin D insufficiency than those with genotype C (P = 0.021), while no association was found between vitamin D status and viral load. In addition, 25-hydroxyvitamin D level did not significantly vary according to activity grade or fibrosis stage. CONCLUSIONS: The prevalence of vitamin D insufficiency is relatively low in our cohort. Patients infected with genotype B had a higher prevalence of vitamin D insufficiency than genotype C. 25-Hydroxyvitamin D serum level is not associated with viral load or fibrosis stage in chronic hepatitis B patients.
BACKGROUND AND AIM: The role of vitamin D playing in patients with chronic hepatitis C has been intensively studied. However, studies on the potential interaction between vitamin D level and chronic hepatitis B are still limited. This study aimed to explore whether any association existed between serum vitamin D level and liver histology or virological parameters in patients with chronic hepatitis B infection in Southern China. METHODS:25-Hydroxyvitamin D serum levels were determined in a cohort of 242 treatment-naïve chronic hepatitis Bpatients. Histologic assessment was based on Knodell histologic activity index and Ishak fibrosis staging. Predictors of vitamin Dinsufficiency were identified using multivariate analysis. RESULTS: Mean 25-hydroxyvitamin D value was 33.90 ng/mL. The percentage of patients with different concentration of 25-hydroxyvitamin D (≥ 30 ng/mL, 20-30 ng/mL, < 20 ng/mL) were 59.9%, 31.4%, and 8.7%, respectively. Gender, season, age, and viral genotype were independent predictors of vitamin Dinsufficiency (< 30 ng/mL). Patients with genotype B virus infection had a lower mean 25-hydroxyvitamin D level (P = 0.023) and higher prevalence of vitamin Dinsufficiency than those with genotype C (P = 0.021), while no association was found between vitamin D status and viral load. In addition, 25-hydroxyvitamin D level did not significantly vary according to activity grade or fibrosis stage. CONCLUSIONS: The prevalence of vitamin Dinsufficiency is relatively low in our cohort. Patients infected with genotype B had a higher prevalence of vitamin Dinsufficiency than genotype C. 25-Hydroxyvitamin D serum level is not associated with viral load or fibrosis stage in chronic hepatitis Bpatients.
Authors: Nghiem Xuan Hoan; Hoang Van Tong; Le Huu Song; Christian G Meyer; Thirumalaisamy P Velavan Journal: World J Gastroenterol Date: 2018-01-28 Impact factor: 5.742
Authors: Bong Jin Ko; Young Seok Kim; Sang Gyune Kim; Jung Hwan Park; Sae Hwan Lee; Soung Won Jeong; Jae Young Jang; Hong Soo Kim; Boo Sung Kim; Sun Mi Kim; Young Don Kim; Gab Jin Cheon; Bo Ra Lee Journal: Gut Liver Date: 2016-09-15 Impact factor: 4.519