AIMS: To image the cones in eyes with anatomically successful repair of retinal detachment (RD) involving the macula and in healthy fellow eyes using an adaptive optics (AO) camera and to correlate the results to clinical outcomes. METHODS: Twenty-one patients (42 eyes) operated for macula-off RD were imaged 6 weeks after surgery using an AO camera (RTX 1, Imagine Eyes, Orsay, France). Cone density (cells/mm(2)), spacing between cells (µm) and the percentage of cones with six neighbours were measured. Best-corrected visual acuity (BCVA) and thickness of the inner segment ellipsoid (ISe) band imaged by SD-optical coherence tomography were also measured. RESULTS: The parafoveal cone density was decreased in eyes operated for RD (mean ± SD 14,576 ± 4035/mm(2)) compared with fellow eyes (20,589 ± 2350/mm(2)) (p=0.0001). There was also an increase in cone spacing (10.3 ± 2.6 vs 8.0 ± 1.0.9 µm, respectively, p<0.0001). The nearest-neighbour analysis revealed a reduction in the percentage of cones with six neighbours (36.5 ± 4.2 vs 42.7 ± 4.6%, p=0.0003). The ISe thickness, thinner in the operated eyes, was correlated to the cone density (r=0.62, p<0.0001). BCVA was significantly correlated to cone density (r=0.8, p<0.001). CONCLUSIONS: There was a decrease in the cone density after RD with an estimated loss of one-third of the cones. Postoperative visual acuity was highly correlated with the cone density. AO may be a valuable prognostic tool after RD surgery. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
AIMS: To image the cones in eyes with anatomically successful repair of retinal detachment (RD) involving the macula and in healthy fellow eyes using an adaptive optics (AO) camera and to correlate the results to clinical outcomes. METHODS: Twenty-one patients (42 eyes) operated for macula-off RD were imaged 6 weeks after surgery using an AO camera (RTX 1, Imagine Eyes, Orsay, France). Cone density (cells/mm(2)), spacing between cells (µm) and the percentage of cones with six neighbours were measured. Best-corrected visual acuity (BCVA) and thickness of the inner segment ellipsoid (ISe) band imaged by SD-optical coherence tomography were also measured. RESULTS: The parafoveal cone density was decreased in eyes operated for RD (mean ± SD 14,576 ± 4035/mm(2)) compared with fellow eyes (20,589 ± 2350/mm(2)) (p=0.0001). There was also an increase in cone spacing (10.3 ± 2.6 vs 8.0 ± 1.0.9 µm, respectively, p<0.0001). The nearest-neighbour analysis revealed a reduction in the percentage of cones with six neighbours (36.5 ± 4.2 vs 42.7 ± 4.6%, p=0.0003). The ISe thickness, thinner in the operated eyes, was correlated to the cone density (r=0.62, p<0.0001). BCVA was significantly correlated to cone density (r=0.8, p<0.001). CONCLUSIONS: There was a decrease in the cone density after RD with an estimated loss of one-third of the cones. Postoperative visual acuity was highly correlated with the cone density. AO may be a valuable prognostic tool after RD surgery. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Authors: Rajeev H Muni; Tina Felfeli; Srinivas R Sadda; Verena R Juncal; Carolina L M Francisconi; Muneeswar Gupta Nittala; Sophiana Lindenberg; Frederic Gunnemann; Alan R Berger; David T Wong; Filiberto Altomare; Louis R Giavedoni; Radha P Kohly; Peter J Kertes; David Sarraf; Roxane J Hillier Journal: JAMA Ophthalmol Date: 2021-06-01 Impact factor: 7.389
Authors: Sana Rasool; Megha Kaushik; Rishika Chaudhary; Karen Blachford; Martin Berry; Robert A H Scott; Ann Logan; Richard J Blanch Journal: Graefes Arch Clin Exp Ophthalmol Date: 2022-01-26 Impact factor: 3.535