Literature DB >> 25237130

Aurea mediocritas: the importance of a balanced genome.

Gianluca Varetti1, David Pellman2, David J Gordon3.   

Abstract

Aneuploidy, defined as an abnormal number of chromosomes, is a hallmark of cancer. Paradoxically, aneuploidy generally has a negative impact on cell growth and fitness in nontransformed cells. In this work, we review recent progress in identifying how aneuploidy leads to genomic and chromosomal instability, how cells can adapt to the deleterious effects of aneuploidy, and how aneuploidy contributes to tumorigenesis in different genetic contexts. Finally, we also discuss how aneuploidy might be a target for anticancer therapies.
Copyright © 2014 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2014        PMID： 25237130      PMCID： PMC4413234          DOI： 10.1101/cshperspect.a015842

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Biol        ISSN： 1943-0264            Impact factor:   10.005


  145 in total

1.  The Stability of Broken Ends of Chromosomes in Zea Mays.

Authors:  B McClintock
Journal:  Genetics       Date:  1941-03       Impact factor: 4.562

2.  Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.

Authors:  Thomas D Barber; Kirk McManus; Karen W Y Yuen; Marcelo Reis; Giovanni Parmigiani; Dong Shen; Irene Barrett; Yasaman Nouhi; Forrest Spencer; Sanford Markowitz; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer; Philip Hieter
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-25       Impact factor: 11.205

Review 3.  Merotelic kinetochore orientation, aneuploidy, and cancer.

Authors:  Daniela Cimini
Journal:  Biochim Biophys Acta       Date:  2008-05-23

4.  Transient nuclear envelope rupturing during interphase in human cancer cells.

Authors:  Jesse D Vargas; Emily M Hatch; Daniel J Anderson; Martin W Hetzer
Journal:  Nucleus       Date:  2012 Jan-Feb       Impact factor: 4.197

5.  Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.

Authors:  Rocío Sotillo; Eva Hernando; Elena Díaz-Rodríguez; Julie Teruya-Feldstein; Carlos Cordón-Cardo; Scott W Lowe; Robert Benezra
Journal:  Cancer Cell       Date:  2006-12-28       Impact factor: 31.743

6.  Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers.

Authors:  N Haruki; H Saito; T Harano; S Nomoto; T Takahashi; H Osada; Y Fujii; T Takahashi
Journal:  Cancer Lett       Date:  2001-01-26       Impact factor: 8.679

7.  Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.

Authors:  Darren J Baker; Fang Jin; Karthik B Jeganathan; Jan M van Deursen
Journal:  Cancer Cell       Date:  2009-12-08       Impact factor: 31.743

Review 8.  Defining 'chromosomal instability'.

Authors:  Jochen B Geigl; Anna C Obenauf; Thomas Schwarzbraun; Michael R Speicher
Journal:  Trends Genet       Date:  2008-01-14       Impact factor: 11.639

Review 9.  The spindle-assembly checkpoint in space and time.

Authors:  Andrea Musacchio; Edward D Salmon
Journal:  Nat Rev Mol Cell Biol       Date:  2007-04-11       Impact factor: 94.444

10.  Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation.

Authors:  J Ramesh Babu; Karthik B Jeganathan; Darren J Baker; Xiaosheng Wu; Ningling Kang-Decker; Jan M van Deursen
Journal:  J Cell Biol       Date:  2003-01-27       Impact factor: 10.539
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  10 in total

1.  HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas.

Authors:  Mianen Sun; Pan Tong; Wen Kong; Baijun Dong; Yiran Huang; In Young Park; Lijun Zhou; Xian-De Liu; Zhiyong Ding; Xuesong Zhang; Shanshan Bai; Peter German; Reid Powell; Quan Wang; Xuefei Tong; Nizar M Tannir; Surena F Matin; W Kimryn Rathmell; Gregory N Fuller; Ian E McCutcheon; Cheryl L Walker; Jing Wang; Eric Jonasch
Journal:  Cancer Res       Date:  2017-08-14       Impact factor: 12.701

2.  The cell cycle stage of bovine zygotes electroporated with CRISPR/Cas9-RNP affects frequency of Loss-of-heterozygosity editing events.

Authors:  Dennis Miskel; Mikhael Poirier; Luisa Beunink; Franca Rings; Eva Held; Ernst Tholen; Dawit Tesfaye; Karl Schellander; Dessie Salilew-Wondim; Carina Blaschka; Christine Große-Brinkhaus; Brenig Bertram; Michael Hoelker
Journal:  Sci Rep       Date:  2022-06-24       Impact factor: 4.996

Review 3.  Somatic mosaicism in the diseased brain.

Authors:  Ivan Y Iourov; Svetlana G Vorsanova; Oxana S Kurinnaia; Sergei I Kutsev; Yuri B Yurov
Journal:  Mol Cytogenet       Date:  2022-10-21       Impact factor: 1.904

4.  The unfolded protein response links tumor aneuploidy to local immune dysregulation.

Authors:  Magalie Dosset; Gonzalo Almanza; Stephen Searles; Su Xian; Paras Sahani; T Cameron Waller; Kristen Jepsen; Hannah Carter; Maurizio Zanetti
Journal:  EMBO Rep       Date:  2021-10-26       Impact factor: 8.807

5.  In silico molecular cytogenetics: a bioinformatic approach to prioritization of candidate genes and copy number variations for basic and clinical genome research.

Authors:  Ivan Y Iourov; Svetlana G Vorsanova; Yuri B Yurov
Journal:  Mol Cytogenet       Date:  2014-12-09       Impact factor: 2.009

Review 6.  Genome management and mismanagement--cell-level opportunities and challenges of whole-genome duplication.

Authors:  Levi Yant; Kirsten Bomblies
Journal:  Genes Dev       Date:  2015-12-01       Impact factor: 11.361

7.  Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing.

Authors:  Styliani Markoulaki; Logan J Blaine; Stamatis Papathanasiou; Mitchell L Leibowitz; Cheng-Zhong Zhang; Rudolf Jaenisch; David Pellman
Journal:  Nat Commun       Date:  2021-10-06       Impact factor: 17.694

Review 8.  The Unfolded Protein Response at the Tumor-Immune Interface.

Authors:  Maurizio Zanetti; Su Xian; Magalie Dosset; Hannah Carter
Journal:  Front Immunol       Date:  2022-02-14       Impact factor: 7.561

9.  DNA demethylation caused by 5-Aza-2'-deoxycytidine induces mitotic alterations and aneuploidy.

Authors:  Giuseppe Costa; Viviana Barra; Laura Lentini; Danilo Cilluffo; Aldo Di Leonardo
Journal:  Oncotarget       Date:  2016-01-26

10.  Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.

Authors:  Mohamed Jemaà; Gwenola Manic; Gwendaline Lledo; Delphine Lissa; Christelle Reynes; Nathalie Morin; Frédéric Chibon; Antonella Sistigu; Maria Castedo; Ilio Vitale; Guido Kroemer; Ariane Abrieu
Journal:  Oncotarget       Date:  2016-01-05
  10 in total

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