| Literature DB >> 25236572 |
Nonanzit Pérez-Hernández1, Gilberto Vargas-Alarcón1, Rocio Arellano-Zapoteco2, Nancy Martínez-Rodríguez1, José Manuel Fragoso1, Gad Aptilon-Duque1, Rosalinda Posadas-Sánchez3, Carlos Posadas-Romero3, Teresa Juárez-Cedillo4, María Lilia Domínguez-López5, José Manuel Rodríguez-Pérez6.
Abstract
The purpose of the present study was to establish the role of DDAH gene polymorphisms in the risk of developing myocardial infarction (MI) in a clinical cohort of Mexican patients. One polymorphism (rs1498373) in the DDAH1 and three in the DDAH2 (rs805304, rs3131383, and rs805305) genes were performed by TaqMan genotyping assays in 473 patients with MI and 447 healthy unrelated controls. Similar distribution of DDAH1 and DDAH2 polymorphisms was observed in MI patients and healthy controls. Under a recessive model adjusted for age, gender, and obesity, the rs805304 C allele was associated with decreased risk of MI (OR = 0.70, 95% CI = 0.51-0.96, P = 0.030). The effect of the polymorphisms on various cardiovascular risk factors was analyzed. Under a recessive model adjusted for age and gender, the DDAH2 rs805304 C allele was associated with decreased risk of obesity (OR = 0.35, 95% CI = 0.22-0.57, P = 0.001). The three DDAH2 polymorphisms were in strong linkage disequilibrium. Our results suggest that the rs805304 C allele was associated with decreased risk of MI and decreased risk of obesity.Entities:
Keywords: Dimethylarginine dimethylaminohydrolase; Haplotypes; Myocardial infarction; Polymorphisms
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Year: 2014 PMID： 25236572 DOI： 10.1016/j.yexmp.2014.09.015
Source DB: PubMed Journal: Exp Mol Pathol ISSN： 0014-4800 Impact factor: 3.362