Literature DB >> 2523468

Pertussis toxin attenuates 5-hydroxytryptamine1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes.

F Okada1, Y Tokumitsu, Y Nomura.   

Abstract

The inhibition of forskolin-stimulated adenylate cyclase activity by 5-hydroxytryptamine (5-HT) receptor agonists was measured in rat hippocampal membranes isolated from animals treated with vehicle or islet-activating protein (IAP; pertussis toxin). In vehicle-treated animals, 5-HT, 8-hydroxy-2-(di-n-propylamino)tetralin, buspirone, and gepirone were potent in inhibiting forskolin-stimulated adenylate cyclase activity with EC50 values of 60, 76, 376, and 530 nM, respectively. IAP treatment reduced by 30-55% the 5-HT1A agonist inhibition of adenylate cyclase activity via 5-HT1A receptors. The data indicate that the inhibitory guanine nucleotide-binding protein or Go (a similar GTP-binding protein of unknown function purified from brain) mediates the 5-HT1A agonist inhibition of hippocampal adenylate cyclase.

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Year:  1989        PMID： 2523468     DOI： 10.1111/j.1471-4159.1989.tb09209.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  7 in total

1.  Neurotransmitter-mediated inhibition of post-mortem human brain adenylyl cyclase.

Authors:  A Garlind; C J Fowler; I Alafuzoff; B Winblad; R F Cowburn
Journal:  J Neural Transm Gen Sect       Date:  1992

2.  Further characterization of 5-HT1A receptors in the goldfish retina: role of cyclic AMP in the regulation of the in vitro outgrowth of retinal explants.

Authors:  C Schmeer; F Obregón; M Urbina; L Lima
Journal:  Neurochem Res       Date:  2001-03       Impact factor: 3.996

3.  Effects of subchronic administration of antidepressants and anxiolytics on levels of the alpha subunits of G proteins in the rat brain.

Authors:  Y Dwivedi; G N Pandey
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

4.  GH4ZD10 cells expressing rat 5-HT1A receptors coupled to adenylyl cyclase are a model for the postsynaptic receptors in the rat hippocampus.

Authors:  C J Fowler; P C Ahlgren; G Brännström
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739

5.  Distribution and localization of 5-HT(1A) receptors in the rat lumbar spinal cord after transection and deafferentation.

Authors:  Chad K Otoshi; Wendy M Walwyn; Niranjala J K Tillakaratne; Hui Zhong; Roland R Roy; V Reggie Edgerton
Journal:  J Neurotrauma       Date:  2009-04       Impact factor: 5.269

6.  G proteins (Gi, Go) in the medial temporal lobe in schizophrenia: preliminary report of a neurochemical correlate of structural change.

Authors:  F Okada; T J Crow; G W Roberts
Journal:  J Neural Transm Gen Sect       Date:  1991

7.  Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia.

Authors:  Rhyomi C Sellnow; Jordan H Newman; Nicole Chambers; Anthony R West; Kathy Steece-Collier; Ivette M Sandoval; Matthew J Benskey; Christopher Bishop; Fredric P Manfredsson
Journal:  Acta Neuropathol Commun       Date:  2019-01-15       Impact factor: 7.801
  7 in total

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