Literature DB >> 25233190

On the interaction of copper(II) with disulfiram.

David J Lewis1, Parikshit Deshmukh, Aleksander A Tedstone, Floriana Tuna, Paul O'Brien.   

Abstract

In combination with copper(II) ions, disulfiram (DSF) has been reported to be a potentially potent anticancer agent based on in vitro results. The interaction of DSF with copper(II) chloride in solution has been studied using a range of spectroscopic techniques. There is strong evidence for the rapid formation of the bis(N,N-diethyl dithiocarbamato)copper(II) complex in situ. Kinetic experiments were used to determine rate laws for the reaction that give insight into the mechanism of the process which may help to explain the observed in vitro cytotoxicity.

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Year:  2014        PMID： 25233190     DOI： 10.1039/c4cc04767b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  25 in total

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Authors:  Alex G Dalecki; Mehri Haeili; Santosh Shah; Alexander Speer; Michael Niederweis; Olaf Kutsch; Frank Wolschendorf
Journal:  Antimicrob Agents Chemother       Date:  2015-06-01       Impact factor: 5.191

2.  Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper.

Authors:  Kelly C Falls-Hubert; Aimee L Butler; Kai Gui; Michael Anderson; Mengshi Li; Jeffrey M Stolwijk; Samuel N Rodman; Shane R Solst; Ann Tomanek-Chalkley; Charles C Searby; Val C Sheffield; Vanessa Sandfort; Hartmut Schmidt; Michael L McCormick; Brian R Wels; Bryan G Allen; Garry R Buettner; Michael K Schultz; Douglas R Spitz
Journal:  Free Radic Biol Med       Date:  2020-02-04       Impact factor: 7.376

3.  Dithiocarbamate prodrugs activated by prostate specific antigen to target prostate cancer.

Authors:  Subha Bakthavatsalam; Petpailin Wiangnak; Daniel J George; Tian Zhang; Katherine J Franz
Journal:  Bioorg Med Chem Lett       Date:  2020-03-28       Impact factor: 2.823

4.  Leveraging γ-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells.

Authors:  Subha Bakthavatsalam; Mark L Sleeper; Azim Dharani; Daniel J George; Tian Zhang; Katherine J Franz
Journal:  Angew Chem Int Ed Engl       Date:  2018-08-29       Impact factor: 15.336

Review 5.  Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity.

Authors:  Maricela Viola-Rhenals; Kush R Patel; Laura Jaimes-Santamaria; Guojun Wu; Jinbao Liu; Q Ping Dou
Journal:  Curr Med Chem       Date:  2018-02-12       Impact factor: 4.530

Review 6.  Connecting copper and cancer: from transition metal signalling to metalloplasia.

Authors:  Eva J Ge; Ashley I Bush; Angela Casini; Paul A Cobine; Justin R Cross; Gina M DeNicola; Q Ping Dou; Katherine J Franz; Vishal M Gohil; Sanjeev Gupta; Stephen G Kaler; Svetlana Lutsenko; Vivek Mittal; Michael J Petris; Roman Polishchuk; Martina Ralle; Michael L Schilsky; Nicholas K Tonks; Linda T Vahdat; Linda Van Aelst; Dan Xi; Peng Yuan; Donita C Brady; Christopher J Chang
Journal:  Nat Rev Cancer       Date:  2021-11-11       Impact factor: 69.800

7.  Metal-binding effects of sirtuin inhibitor sirtinol.

Authors:  Eman A Akam; Ritika Gautam; Elisa Tomat
Journal:  Supramol Chem       Date:  2015-10-15       Impact factor: 1.688

8.  Combination of Disulfiram and Copper-Cysteamine Nanoparticles for an Enhanced Antitumor Effect on Esophageal Cancer.

Authors:  Yan Chang; Fang Wu; Nil Kanatha Pandey; Lalit Chudal; Meiying Xing; Xiaoli Zhang; Linh Nguyen; Xian Liu; J Ping Liu; Wei Chen; Zui Pan
Journal:  ACS Appl Bio Mater       Date:  2020-09-09

9.  Cancer cell-selective killing polymer/copper combination.

Authors:  Huacheng He; Diego Altomare; Ufuk Ozer; Hanwen Xu; Kim Creek; Hexin Chen; Peisheng Xu
Journal:  Biomater Sci       Date:  2016-01       Impact factor: 6.843

10.  Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations.

Authors:  Hamidreza Fasehee; Rassoul Dinarvand; Ardeshir Ghavamzadeh; Mehdi Esfandyari-Manesh; Hanieh Moradian; Shahab Faghihi; Seyed Hamidollah Ghaffari
Journal:  J Nanobiotechnology       Date:  2016-04-21       Impact factor: 10.435
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