Fei Li1, Ke Xia, Chuanchang Li, Tianlun Yang. 1. Department of Cardiology (FL, KX, TY), Xiangya Hospital, Central South University, Changsha, China; Institute of Molecular Medicine and Surgery (MMK) (KX), Karolinska Hospital, Stockholm, Sweden; Department of Geriatrics (CL), Xiangya Hospital, Central South University, Changsha, China; and Institute of Hypertension (TY), Central South University, Changsha, China.
Abstract
BACKGROUND: Retinol-binding protein 4 (RBP4) is an adipokine associated with insulin resistance (IR) and obesity-related metabolic disorders. To evaluate its association with cardiovascular disease, we compared serum RBP4 concentrations in patients with coronary artery disease (CAD) and in controls. METHODS: Sixty patients with coronary angiography-confirmed CAD, including 30 with CAD and 30 with CAD and hyperinsulinemia (CAD/HIns group), and 29 healthy subjects were enrolled. Serum RBP4, IR indexes and cardiovascular risk factors were assessed in these subjects. RESULTS: Serum RBP4 concentrations were significantly higher in the CAD/HIns than in the CAD and control groups (P < 0.01 each). RBP4 concentration was significantly associated with cardiovascular risk factors, including body mass index and concentrations of triglycerides, high-density lipoprotein cholesterol, uric acid, high-sensitivity C reactive protein and adiponectin (P < 0.01 each). Two-hour postprandial insulin (β = 0.224), homeostatic model assessment of IR score (β = 0.456) and adiponectin concentration (β = 0.294) were independent factors associated with RBP4 (P < 0.01 each). CONCLUSIONS: RBP4 concentration is associated with cardiovascular risk factors related to IR and CAD. Circulating RBP4 could be a marker of metabolic complications and atherosclerosis and could be used to assess CAD.
BACKGROUND:Retinol-binding protein 4 (RBP4) is an adipokine associated with insulin resistance (IR) and obesity-related metabolic disorders. To evaluate its association with cardiovascular disease, we compared serum RBP4 concentrations in patients with coronary artery disease (CAD) and in controls. METHODS: Sixty patients with coronary angiography-confirmed CAD, including 30 with CAD and 30 with CAD and hyperinsulinemia (CAD/HIns group), and 29 healthy subjects were enrolled. Serum RBP4, IR indexes and cardiovascular risk factors were assessed in these subjects. RESULTS: Serum RBP4 concentrations were significantly higher in the CAD/HIns than in the CAD and control groups (P < 0.01 each). RBP4 concentration was significantly associated with cardiovascular risk factors, including body mass index and concentrations of triglycerides, high-density lipoprotein cholesterol, uric acid, high-sensitivity C reactive protein and adiponectin (P < 0.01 each). Two-hour postprandial insulin (β = 0.224), homeostatic model assessment of IR score (β = 0.456) and adiponectin concentration (β = 0.294) were independent factors associated with RBP4 (P < 0.01 each). CONCLUSIONS:RBP4 concentration is associated with cardiovascular risk factors related to IR and CAD. Circulating RBP4 could be a marker of metabolic complications and atherosclerosis and could be used to assess CAD.
Authors: Katya B Rubinow; Clark M Henderson; Cassianne Robinson-Cohen; Jonathan Himmelfarb; Ian H de Boer; Tomas Vaisar; Bryan Kestenbaum; Andrew N Hoofnagle Journal: Kidney Int Date: 2017-07-26 Impact factor: 10.612
Authors: Ekaterina M Stakhneva; Irina A Meshcheryakova; Evgeny A Demidov; Konstantin V Starostin; Sergey E Peltek; Michael I Voevoda; Yuliya I Ragino Journal: J Med Biochem Date: 2020-01-23 Impact factor: 3.402