Literature DB >> 2523284

Cataract prevention in diabetic Octodon degus with Pfizer's sorbinil.

M B Datiles1, H Fukui.   

Abstract

The Octodon degus has been reported to have higher aldose reductase activity in the lens compared to the gerbil and rat. When made diabetic the degus develop cataracts within 4 weeks. We have been able to completely prevent cataract formation in diabetic degus using Pfizer's sorbinil for up to 6 months. This is further evidence of the role of aldose reductase in the formation of cataracts in diabetes.

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Year:  1989        PMID： 2523284     DOI： 10.3109/02713688908997564

Source DB:  PubMed          Journal:  Curr Eye Res        ISSN： 0271-3683            Impact factor:   2.424


  7 in total

1.  Topical KINOSTAT™ ameliorates the clinical development and progression of cataracts in dogs with diabetes mellitus.

Authors:  Peter F Kador; Terah R Webb; Dineli Bras; Kerry Ketring; Milton Wyman
Journal:  Vet Ophthalmol       Date:  2010-11       Impact factor: 1.644

2.  Changes in the lens epithelium with respect to cataractogenesis: light microscopic and Scheimpflug densitometric analysis of the cataractous and the clear lens of diabetics and non-diabetics.

Authors:  Sergey I Tkachov; Christine Lautenschläger; Dirk Ehrich; Hans Gert Struck
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2005-09-21       Impact factor: 3.117

3.  Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.

Authors:  Viktor R Drel; Pal Pacher; Tayyeba K Ali; Jeho Shin; Ulrich Julius; Azza B El-Remessy; Irina G Obrosova
Journal:  Int J Mol Med       Date:  2008-06       Impact factor: 4.101

4.  Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract.

Authors:  Kun-Che Chang; Linfeng Li; Theresa M Sanborn; Biehuoy Shieh; Patricia Lenhart; David Ammar; Daniel V LaBarbera; J Mark Petrash
Journal:  J Nat Prod       Date:  2016-05-03       Impact factor: 4.050

5.  Clinical detection of precataractous lens protein changes using dynamic light scattering.

Authors:  Manuel B Datiles; Rafat R Ansari; Kwang I Suh; Susan Vitale; George F Reed; J Samuel Zigler; Frederick L Ferris
Journal:  Arch Ophthalmol       Date:  2008-12

6.  Brain Transcriptome Sequencing of a Natural Model of Alzheimer's Disease.

Authors:  Francisco Altimiras; Barbara Uszczynska-Ratajczak; Francisco Camara; Anna Vlasova; Emilio Palumbo; Stephen Newhouse; Robert M J Deacon; Leandro A E Farias; Michael J Hurley; David E Loyola; Rodrigo A Vásquez; Richard Dobson; Roderic Guigó; Patricia Cogram
Journal:  Front Aging Neurosci       Date:  2017-03-20       Impact factor: 5.750

Review 7.  In Search of Differential Inhibitors of Aldose Reductase.

Authors:  Francesco Balestri; Roberta Moschini; Umberto Mura; Mario Cappiello; Antonella Del Corso
Journal:  Biomolecules       Date:  2022-03-22
  7 in total

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