Yan Zhou1, Yan Kang1, Zhongwei Zhang1, Jin Liu2. 1. Department of ICU, West China Hospital of Sichuan University Chengdu, Sichuan, China. 2. Department of Anesthesiology, West China Hospital of Sichuan University Chengdu, Sichuan, China.
Abstract
BACKGROUND AND OBJECTIVES: It has been reported that host genetic factors may play a crucial role in pneumoconiosis susceptibility. The present study aimed to study the association between IL-1RA +2018 polymorphism and pneumoconiosis by Meta-analysis. MATERIALS AND METHODS: Literatures addressing the association between IL-1RA gene polymorphisms and pneumoconiosis were selected from the PubMed, Cochrane Library, EMBASE, CNKI and Wanfang databases. Statistical analyses were performed by Review Manager Software 5.0.24 and STATA 11.0 software. RESULTS: 5 case-control studies with a total of 609 pneumoconiosis patients and 579 controls were retrieved. Meta-analysis results showed significant association between IL-1RA +2018 polymorphism and pneumoconiosis risk. The C allele carriers have increased risk compared with the T allele carriers (OR=1.68, 95% CI: 1.25-2.27, P=0.0007). Individuals who carry TC or CC genotype have higher risk than those with TT homozygote (OR=1.79, 95% CI: 1.18, 2.71, P=0.006). In subgroup analysis by pneumoconiosis type, a significant association between IL-1RA +2018 polymorphism and pneumoconiosis risk were found in silicosis (C vs T: OR=2.12, 95% CI: 1.63-2.76, P=0.000; TC+CC vs TT: OR=1.79, 95% CI: 1.18-2.71, P=0.006) but not in coal workers' pneumoconiosis. CONCLUSION: This Meta-analysis suggests that IL-1RA +2018 polymorphism might be risk factors for pneumoconiosis, especially in silicosis.
BACKGROUND AND OBJECTIVES: It has been reported that host genetic factors may play a crucial role in pneumoconiosis susceptibility. The present study aimed to study the association between IL-1RA +2018 polymorphism and pneumoconiosis by Meta-analysis. MATERIALS AND METHODS: Literatures addressing the association between IL-1RA gene polymorphisms and pneumoconiosis were selected from the PubMed, Cochrane Library, EMBASE, CNKI and Wanfang databases. Statistical analyses were performed by Review Manager Software 5.0.24 and STATA 11.0 software. RESULTS: 5 case-control studies with a total of 609 pneumoconiosispatients and 579 controls were retrieved. Meta-analysis results showed significant association between IL-1RA +2018 polymorphism and pneumoconiosis risk. The C allele carriers have increased risk compared with the T allele carriers (OR=1.68, 95% CI: 1.25-2.27, P=0.0007). Individuals who carry TC or CC genotype have higher risk than those with TT homozygote (OR=1.79, 95% CI: 1.18, 2.71, P=0.006). In subgroup analysis by pneumoconiosis type, a significant association between IL-1RA +2018 polymorphism and pneumoconiosis risk were found in silicosis (C vs T: OR=2.12, 95% CI: 1.63-2.76, P=0.000; TC+CC vs TT: OR=1.79, 95% CI: 1.18-2.71, P=0.006) but not in coal workers' pneumoconiosis. CONCLUSION: This Meta-analysis suggests that IL-1RA +2018 polymorphism might be risk factors for pneumoconiosis, especially in silicosis.
Authors: B Yucesoy; V Vallyathan; D P Landsittel; D S Sharp; A Weston; G R Burleson; P Simeonova; M McKinstry; M I Luster Journal: Toxicol Appl Pharmacol Date: 2001-04-01 Impact factor: 4.219
Authors: José Jesús Blanco-Pérez; Sara Blanco-Dorado; Javier Rodríguez-García; Mª Elena Gonzalez-Bello; Ángel Salgado-Barreira; Adriana Carolina Caldera-Díaz; Abel Pallarés-Sanmartín; Alberto Fernandez-Villar; Francisco Javier González-Barcala Journal: Sci Rep Date: 2021-06-25 Impact factor: 4.379