BACKGROUND: Extraesophageal reflux exists as shown by scientific data. The underlying pathophysiology is not yet exactly known. Functional endoscopy seems to be a promising new diagnostic instrument. This study determined the relationship between functional endoscopy and Belafsky's reflux symptom index (RSI). METHODS: In this study 71 patients were prospectively included and underwent a functional endoscopic examination followed by 6 months of proton pump inhibitor (PPI) therapy. Symptoms were scored using Belafsky's RSI after endoscopic examination (before treatment) and after 3 and 6 months of PPI therapy. RESULTS: After 3 and 6 months of PPI-therapy significant decreases in the RSI were found. The functional endoscopy characteristics which were expected to remain constant were controlled after 6 months and found to be nearly 100 % reproducible. Patients profit from PPI- therapy when reflux is detected by endoscopy even when RSI was initally normal. Functional endoscopy seems to be a useful instrument to detect extraesophageal reflux.
BACKGROUND: Extraesophageal reflux exists as shown by scientific data. The underlying pathophysiology is not yet exactly known. Functional endoscopy seems to be a promising new diagnostic instrument. This study determined the relationship between functional endoscopy and Belafsky's reflux symptom index (RSI). METHODS: In this study 71 patients were prospectively included and underwent a functional endoscopic examination followed by 6 months of proton pump inhibitor (PPI) therapy. Symptoms were scored using Belafsky's RSI after endoscopic examination (before treatment) and after 3 and 6 months of PPI therapy. RESULTS: After 3 and 6 months of PPI-therapy significant decreases in the RSI were found. The functional endoscopy characteristics which were expected to remain constant were controlled after 6 months and found to be nearly 100 % reproducible. Patients profit from PPI- therapy when reflux is detected by endoscopy even when RSI was initally normal. Functional endoscopy seems to be a useful instrument to detect extraesophageal reflux.
Authors: J Behr; A Günther; W Ammenwerth; I Bittmann; R Bonnet; R Buhl; O Eickelberg; R Ewert; S Gläser; J Gottlieb; C Grohé; M Kreuter; C Kroegel; P Markart; C Neurohr; M Pfeifer; A Prasse; N Schönfeld; J Schreiber; H Sitter; D Theegarten; A Theile; A Wilke; H Wirtz; C Witt; H Worth; P Zabel; J Müller-Quernheim; U Costabel Journal: Pneumologie Date: 2013-01-16
Authors: Oliver O Koch; Stavros A Antoniou; Adolf Kaindlstorfer; Kai U Asche; Frank A Granderath; Rudolph Pointner Journal: Surg Laparosc Endosc Percutan Tech Date: 2012-10 Impact factor: 1.719
Authors: Oliver O Koch; Adolf Kaindlstorfer; Stavros A Antoniou; Ruzica Rosalia Luketina; Klaus Emmanuel; Rudolph Pointner Journal: Surg Endosc Date: 2013-01-30 Impact factor: 4.584