Literature DB >> 25231082

In situ monitoring of intracellular controlled drug release from mesoporous silica nanoparticles coated with pH-responsive charge-reversal polymer.

Peng Zhang1, Tong Wu, Ji-Lie Kong.   

Abstract

Therapeutic platforms such as chemotherapy that respond to physical and biological stimuli are highly desirable for effective cancer therapy. In this study, pH-responsive charge-reversal, polymer-coated mesoporous silica nanoparticles [PAH-cit/APTES-MSNs; PAH-cit refers to poly(allylamine)-citraconic anhydride; APTES refers to (3-aminopropyl)triethoxysilane] were synthesized for application as drug-delivery systems for the treatment of malignant cells. Confocal laser scanning microscopy (CLSM) revealed that the PAH-cit/APTES-MSNs nanocomposite effectively delivered and released doxorubicin hydrochloride to the nucleus of HeLa (human cervical carcinoma) cells. Additionally, the real-time dynamic drug-release process was monitored by CLSM. The current pH-controlled-smart-release platform holds promise in drug-delivery and cancer therapy-related applications.

Entities:  

Keywords:  doxorubicin hydrochloride; drug delivery; mesoporous silica nanoparticles; pH-controlled release; pH-responsive charge-reversal polymer

Mesh：

Substances：

Year:  2014        PMID： 25231082     DOI： 10.1021/am5059519

Source DB:  PubMed          Journal:  ACS Appl Mater Interfaces        ISSN： 1944-8244            Impact factor:   9.229


  9 in total

1.  Colorimetric DNA assay by exploiting the DNA-controlled peroxidase mimicking activity of mesoporous silica loaded with platinum nanoparticles.

Authors:  Weiwei Chen; Xueen Fang; Xin Ye; Xinjun Wang; Jilie Kong
Journal:  Mikrochim Acta       Date:  2018-11-12       Impact factor: 5.833

Review 2.  pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery.

Authors:  Miguel Gisbert-Garzarán; Miguel Manzano; María Vallet-Regí
Journal:  Bioengineering (Basel)       Date:  2017-01-18

Review 3.  Nanotechnology in bone tissue engineering.

Authors:  Graham G Walmsley; Adrian McArdle; Ruth Tevlin; Arash Momeni; David Atashroo; Michael S Hu; Abdullah H Feroze; Victor W Wong; Peter H Lorenz; Michael T Longaker; Derrick C Wan
Journal:  Nanomedicine       Date:  2015-03-16       Impact factor: 5.307

4.  Sustained Delivery Growth Factors with Polyethyleneimine-Modified Nanoparticles Promote Embryonic Stem Cells Differentiation and Liver Regeneration.

Authors:  Meiyan Wang; Xiaomei Yang; Peng Zhang; Lei Cai; Xibin Yang; Youwei Chen; Yuanya Jing; Jilie Kong; Xiaowei Yang; Fang-Lin Sun
Journal:  Adv Sci (Weinh)       Date:  2016-04-08       Impact factor: 16.806

Review 5.  Possible role of nanocarriers in drug delivery against cervical cancer.

Authors:  Swati Gupta; Manish K Gupta
Journal:  Nano Rev Exp       Date:  2017-07-07

6.  Facile synthesis by a covalent binding reaction for pH-responsive drug release of carboxylated chitosan coated hollow mesoporous silica nanoparticles.

Authors:  Qiang Liu; Jiao Wang; Linnan Yang; Xiaofei Xia; Mei Wang; Shengguang Chen; Rongrong Zhu; Qingxiu Wang; Xianzheng Wu; Shilong Wang
Journal:  IET Nanobiotechnol       Date:  2018-06       Impact factor: 1.847

7.  Construction of A Triple-Stimuli-Responsive System Based on Cerium Oxide Coated Mesoporous Silica Nanoparticles.

Authors:  Jia Wen; Kui Yang; Yongqian Xu; Hongjuan Li; Fengyu Liu; Shiguo Sun
Journal:  Sci Rep       Date:  2016-12-12       Impact factor: 4.379

8.  pH-responsive charge-reversal polymer-functionalized boron nitride nanospheres for intracellular doxorubicin delivery.

Authors:  Shini Feng; Huijie Zhang; Chunyi Zhi; Xiao-Dong Gao; Hideki Nakanishi
Journal:  Int J Nanomedicine       Date:  2018-01-31

9.  Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy.

Authors:  Thashini Moodley; Moganavelli Singh
Journal:  Molecules       Date:  2020-02-08       Impact factor: 4.411
  9 in total

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