Literature DB >> 2523098

Cardiac allograft prolongation in mice treated with combined posttransplantation total-lymphoid irradiation and anti-L3T4 antibody therapy.

D K Trager1, B A Banks, G E Rosenbaum, B I Holm, J A Shizuru, S Strober, C G Fathman.   

Abstract

Neonatal cardiac allograft survival was examined in mice treated with anti-L3T4 antibody, posttransplantation total lymphoid irradiation (TLI) or a combination of both therapies. Independently, both posttransplantation TLI and short-course antibody treatment allowed minimal prolongation. However, synergistic prolongation in graft survival was observed with the combination (synergistic) therapy. Fluorescence-activated cell sorter analysis of peripheral blood lymphocytes from animals treated with combined anti-L3T4 and posttransplantation TLI additionally revealed "synergy" with respect to the degree of peripheral lymphocyte depletion.

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Year:  1989        PMID： 2523098     DOI： 10.1097/00007890-198904000-00004

Source DB:  PubMed          Journal:  Transplantation        ISSN： 0041-1337            Impact factor:   4.939


  6 in total

1.  Interactions between NKT cells and Tregs are required for tolerance to combined bone marrow and organ transplants.

Authors:  David Hongo; Xiaobin Tang; Suparna Dutt; Roland G Nador; Samuel Strober
Journal:  Blood       Date:  2011-12-15       Impact factor: 22.113

2.  Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance.

Authors:  D Hongo; X Tang; J Baker; E G Engleman; S Strober
Journal:  Am J Transplant       Date:  2014-10-13       Impact factor: 8.086

3.  Tolerogenic interactions between CD8+ dendritic cells and NKT cells prevent rejection of bone marrow and organ grafts.

Authors:  David Hongo; Xiaobin Tang; Xiangyue Zhang; Edgar G Engleman; Samuel Strober
Journal:  Blood       Date:  2017-01-17       Impact factor: 22.113

4.  Low energy X-ray (grenz ray) treatment of purified islets prior to allotransplant markedly decreases passenger leukocyte populations.

Authors:  Rena Pawlick; Boris Gala-Lopez; Andrew R Pepper; Nasser Abualhassan; Antonio Bruni; Kunimasa Suzuki; Gina Rayat; John F Elliott; A M James Shapiro
Journal:  Islets       Date:  2017-07-10       Impact factor: 2.694

5.  The changed balance of regulatory and naive T cells promotes tolerance after TLI and anti-T-cell antibody conditioning.

Authors:  R G Nador; D Hongo; J Baker; Z Yao; S Strober
Journal:  Am J Transplant       Date:  2009-12-23       Impact factor: 8.086

Review 6.  Allorecognition by T Lymphocytes and Allograft Rejection.

Authors:  Jose Marino; Joshua Paster; Gilles Benichou
Journal:  Front Immunol       Date:  2016-12-14       Impact factor: 7.561
  6 in total

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