| Literature DB >> 25230932 |
Abstract
The small GTPase Arf1 that is classically required for the budding of COPI-coated vesicles from the Golgi membrane is now proposed to have novel and conserved roles in the morphological and functional maintenance of mitochondria: It functionally localizes to ER/mitochondria contact sites; it allows for the recruitment of a degradation machinery to mitochondria to remove toxic mitofusin/Fzo1 clusters; and it allows the extension of autophagy sequestration membranes needed for mitophagy to clear damaged mitochondria.Entities:
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Year: 2014 PMID: 25230932 PMCID: PMC4282570 DOI: 10.15252/embj.201489899
Source DB: PubMed Journal: EMBO J ISSN: 0261-4189 Impact factor: 11.598