INTRODUCTION: Cryptococcosis is an opportunistic mycosis, especially in patients that are human immunodeficiency virus (HIV)-positive, and frequently involves the central nervous system. METHODS: We assessed the potential of ventriculoperitoneal shunting (VPS) in preventing mortality due to uncontrollable intracranial hypertension (ICH) in 15 patients with acquired immunodeficiency syndrome (AIDS)-related cryptococcal meningitis. RESULTS: After 2 weeks of antifungal therapy consisting of amphotericin B deoxycholate with or without fluconazole, patients with persistent ICH underwent VPS, despite having persistent Cryptococcus neoformans infection. In 12 patients, the uncontrollable ICH was resolved by VPS. CONCLUSIONS: Patients with cryptococcal meningoencephalitis who have ICH must be considered for VPS even with positive cerebrospinal fluid cultures.
INTRODUCTION:Cryptococcosis is an opportunistic mycosis, especially in patients that are human immunodeficiency virus (HIV)-positive, and frequently involves the central nervous system. METHODS: We assessed the potential of ventriculoperitoneal shunting (VPS) in preventing mortality due to uncontrollable intracranial hypertension (ICH) in 15 patients with acquired immunodeficiency syndrome (AIDS)-related cryptococcal meningitis. RESULTS: After 2 weeks of antifungal therapy consisting of amphotericin B deoxycholate with or without fluconazole, patients with persistent ICH underwent VPS, despite having persistent Cryptococcus neoformansinfection. In 12 patients, the uncontrollable ICH was resolved by VPS. CONCLUSIONS:Patients with cryptococcal meningoencephalitis who have ICH must be considered for VPS even with positive cerebrospinal fluid cultures.
Authors: Tatiane Benaducci; Janaina de C O Sardi; Natalia M S Lourencetti; Liliana Scorzoni; Fernanda P Gullo; Suélen A Rossi; Jaqueline B Derissi; Márcia C de Azevedo Prata; Ana M Fusco-Almeida; Maria J S Mendes-Giannini Journal: Front Microbiol Date: 2016-03-09 Impact factor: 5.640
Authors: John W Baddley; George R Thompson; Kristen O Riley; Mary K Moore; Stephen A Moser; Peter G Pappas Journal: Open Forum Infect Dis Date: 2019-05-20 Impact factor: 3.835
Authors: Enock Kagimu; Nicole Engen; Kenneth Ssebambulidde; John Kasibante; Tadeo K Kiiza; Edward Mpoza; Lillian Tugume; Edwin Nuwagira; Laura Nsangi; Darlisha A Williams; Kathy Huppler Hullsiek; David R Boulware; David B Meya; Joshua Rhein; Mahsa Abassi; Abdu K Musubire Journal: Open Forum Infect Dis Date: 2022-08-17 Impact factor: 4.423