Literature DB >> 25229226

First report on ototoxicity of meglumine antimoniate.

Cláudia Maria Valete-Rosalino1, Maria Helena Araujo-Melo1, Débora Cristina de Oliveira Bezerra2, Renata Oliveira de Barcelos2, Vanessa de Melo-Ferreira1, Tânia Salgado de Sousa Torraca1, Ana Cristina da Costa Martins1, João Soares Moreira1, Mirian Catherine Melgares Vargas1, Frederico Pereira Bom Braga1, Mariza de Matos Salgueiro1, Maurício Naoto Saheki1, Armando Oliveira Schubach1.   

Abstract

INTRODUCTION: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. CASE REPORT: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted.
CONCLUSION: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate.

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Year:  2014        PMID： 25229226      PMCID： PMC4172117          DOI： 10.1590/s0036-46652014000500012

Source DB:  PubMed          Journal:  Rev Inst Med Trop Sao Paulo        ISSN： 0036-4665            Impact factor:   1.846


  12 in total

1.  Risk factors associated with dizziness during treatment of mucosal leishmaniasis with meglumine antimoniate: 16-year retrospective study of cases from Rio de Janeiro, Brazil.

Authors:  M H Araujo-Melo; A M Meneses; A O Schubach; J S Moreira; F Conceição-Silva; M M Salgueiro; M I F Pimentel; M Araújo-Silva; R V C Oliveira; C N Carmo; C M Valete-Rosalino
Journal:  J Laryngol Otol       Date:  2010-06-11       Impact factor: 1.469

2.  [A study of a focus of mucocutaneous leishmaniasis in lowlands of the state of Rio de Janeiro].

Authors:  F NERY-GUIMARAES
Journal:  Mem Inst Oswaldo Cruz       Date:  1955-05       Impact factor: 2.743

3.  American tegumentary leishmaniasis in older adults: 44 cases treated with an intermittent low-dose antimonial schedule in Rio de Janeiro, Brazil.

Authors:  Erica de Camargo Ferreira E Vasconcellos; Armando de Oliveira Schubach; Cláudia Maria Valete-Rosalino; Renata de Souza Coutinho; Fátima Conceição-Silva; Mariza de Matos Salgueiro; Marcelo Rosandiski Lyra; João Soares Moreira; Rilza Beatriz Azeredo-Coutinho; Maria Inês Fernandes Pimentel; Sergio Roberto Mortari; Maria de Fátima Madeira; Leonardo Pereira Quintella; Cibele Baptista; Mauro Célio de Almeida Marzochi
Journal:  J Am Geriatr Soc       Date:  2010-03       Impact factor: 5.562

Review 4.  Drug-induced tinnitus and other hearing disorders.

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Journal:  Drug Saf       Date:  1996-03       Impact factor: 5.606

5.  Pharmacokinetics of antimony during treatment of visceral leishmaniasis with sodium stibogluconate or meglumine antimoniate.

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Journal:  Trans R Soc Trop Med Hyg       Date:  1988       Impact factor: 2.184

Review 6.  Systematic review of the adverse effects of cutaneous leishmaniasis treatment in the New World.

Authors:  Luiz F Oliveira; Armando O Schubach; Maria M Martins; Sônia L Passos; Raquel V Oliveira; Mauro C Marzochi; Carlos A Andrade
Journal:  Acta Trop       Date:  2011-03-21       Impact factor: 3.112

7.  Monitoring of total antimony and its species by ICP-MS and on-line ion chromatography in biological samples from patients treated for leishmaniasis.

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Journal:  Rev Soc Bras Med Trop       Date:  2001 Jan-Feb       Impact factor: 1.581

Review 9.  Antivertigo medications and drug-induced vertigo. A pharmacological review.

Authors:  O Rascol; T C Hain; C Brefel; M Benazet; M Clanet; J L Montastruc
Journal:  Drugs       Date:  1995-11       Impact factor: 9.546

10.  Monitoring toxicity associated with parenteral sodium stibogluconate in the day-case management of returned travellers with New World cutaneous leishmaniasis [corrected].

Authors:  Emily S Wise; Margaret S Armstrong; Julie Watson; Diana N Lockwood
Journal:  PLoS Negl Trop Dis       Date:  2012-06-26
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  1 in total

1.  Alterations in Evoked Otoacoustic Emissions by the Use of Meglumine Antimoniate in American Tegumentary Leishmaniasis Patients.

Authors:  Débora Cristina de Oliveira Bezerra; Renata Oliveira de Barcelos; Ellen Carvalho de Castro; Claudia Cristina Jardim Duarte; Raquel de Vasconcellos Carvalhaes Oliveira; Tania Salgado de Sousa Torraca; Maria Helena de Araújo-Melo; Frederico Pereira Bom Braga; Benivaldo Ramos Ferreira Terceiro; Lúcia Regina do Nascimento Brahim Paes; Armando de Oliveira Schubach; Cláudia Maria Valete-Rosalino
Journal:  PLoS One       Date:  2017-01-03       Impact factor: 3.240
  1 in total

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