Literature DB >> 25228957

Interferon-γ and other inflammatory mediators in cardiomyocyte signaling during Chagas disease cardiomyopathy.

Ludmila Rodrigues Pinto Ferreira1, Amanda Farage Frade1, Monique Andrade Baron1, Isabela Cunha Navarro1, Jorge Kalil1, Christophe Chevillard1, Edecio Cunha-Neto1.   

Abstract

Chagas disease cardiomyopathy (CCC), the main consequence of Trypanosoma cruzi (T.cruzi) infection, is an inflammatory cardiomyopathy that develops in up to 30% of infected individuals. The heart inflammation in CCC patients is characterized by a Th1 T cell-rich myocarditis with increased production of interferon (IFN)-γ, produced by the CCC myocardial infiltrate and detected at high levels in the periphery. IFN-γ has a central role in the cardiomyocyte signaling during both acute and chronic phases of T.cruzi infection. In this review, we have chosen to focus in its pleiotropic mode of action during CCC, which may ultimately be the strongest driver towards pathological remodeling and heart failure. We describe here the antiparasitic protective and pathogenic dual role of IFN-γ in Chagas disease.

Entities:  

Keywords:  Cardiomyopathy; Chagas disease; Gene expression; Interferon-gamma; Trypanosoma cruzi

Year:  2014        PMID： 25228957      PMCID： PMC4163707          DOI： 10.4330/wjc.v6.i8.782

Source DB:  PubMed          Journal:  World J Cardiol


  79 in total

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  21 in total

1.  Interleukin 10 Polymorphisms as Risk Factors for Progression to Chagas Disease Cardiomyopathy: A Case-Control Study and Meta-Analysis.

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Journal:  Front Immunol       Date:  2022-07-04       Impact factor: 8.786

2.  Prolonged dipyridamole administration reduces myocardial perfusion defects in experimental chronic Chagas cardiomyopathy.

Authors:  Denise Mayumi Tanaka; Luciano Fonseca Lemos de Oliveira; José Antônio Marin-Neto; Minna Moreira Dias Romano; Eduardo Elias Vieira de Carvalho; Antonio Carlos Leite de Barros Filho; Fernando Fonseca França Ribeiro; Jorge Mejia Cabeza; Carla Duque Lopes; Camila Godoy Fabricio; Norival Kesper; Henrique Turin Moreira; Lauro Wichert-Ana; André Schmidt; Maria de Lourdes Higuchi; Edécio Cunha-Neto; Marcus Vinícius Simões
Journal:  J Nucl Cardiol       Date:  2018-02-01       Impact factor: 5.952

Review 3.  Trypanosoma cruzi parasites fight for control of the JAK-STAT pathway by disarming their host.

Authors:  Philipp Stahl; Ralph T Schwarz; Françoise Debierre-Grockiego; Thomas Meyer
Journal:  JAKSTAT       Date:  2015-02-03

4.  Integration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infection.

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5.  Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial.

Authors:  Anis Rassi; José Antonio Marin; Anis Rassi
Journal:  Mem Inst Oswaldo Cruz       Date:  2017-02-16       Impact factor: 2.743

6.  Cynomolgus macaques naturally infected with Trypanosoma cruzi-I exhibit an overall mixed pro-inflammatory/modulated cytokine signature characteristic of human Chagas disease.

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Review 7.  Infectious myocarditis: the role of the cardiac vasculature.

Authors:  Linde Woudstra; Lynda J M Juffermans; Albert C van Rossum; Hans W M Niessen; Paul A J Krijnen
Journal:  Heart Fail Rev       Date:  2018-07       Impact factor: 4.214

8.  Targeting Myeloid-Derived Suppressor Cells to Enhance a Trans-Sialidase-Based Vaccine Against Trypanosoma cruzi.

Authors:  Juan Cruz Gamba; Carolina Roldán; Estefanía Prochetto; Giuliana Lupi; Iván Bontempi; Carolina Verónica Poncini; Mónica Vermeulen; Ana Rosa Pérez; Iván Marcipar; Gabriel Cabrera
Journal:  Front Cell Infect Microbiol       Date:  2021-07-06       Impact factor: 5.293

9.  Genetic Susceptibility to Cardiac and Digestive Clinical Forms of Chronic Chagas Disease: Involvement of the CCR5 59029 A/G Polymorphism.

Authors:  Amanda Priscila de Oliveira; Cássia Rubia Bernardo; Ana Vitória da Silveira Camargo; Luiz Sérgio Ronchi; Aldenis Albaneze Borim; Cinara Cássia Brandão de Mattos; Eumildo de Campos Júnior; Lílian Castiglioni; João Gomes Netinho; Carlos Eugênio Cavasini; Reinaldo Bulgarelli Bestetti; Luiz Carlos de Mattos
Journal:  PLoS One       Date:  2015-11-23       Impact factor: 3.240

Review 10.  Macropinocytosis: a pathway to protozoan infection.

Authors:  Tecia M U de Carvalho; Emile S Barrias; Wanderley de Souza
Journal:  Front Physiol       Date:  2015-04-09       Impact factor: 4.566
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