Literature DB >> 2522841

The CD4 Leu 8- T helper cell in colonic mucosa: a quantitative and functional analysis.

R H Ming1, R G Strickland, M Listrom, C Fenoglio-Preiser.   

Abstract

CD4 T cells in the colonic lamina propria are primarily B cell helper as identified by their surface phenotype CD4 Leu 8- (CD4 Leu 8+:CD4 Leu 8- ratio = 1:3.5). This is in contrast to autologous peripheral blood where CD4 Leu 8+ cells predominate (CD4 Leu 8+:CD4 Leu 8- ratio = 2.4:1). Functionally CD4 Leu 8- T cells isolated from the colon are able to provide autologous peripheral blood B cell help comparable to that of peripheral blood CD4 Leu 8- T cells. Immunoperoxidase staining of colonic tissue sections confirmed the relative lack of Leu 8 staining cells in the lamina propria and that when present these cells are located in the outer margins of lymphoid follicles.

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Year:  1989        PMID： 2522841      PMCID： PMC1542122     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  8 in total

1.  Induction of CD4 suppressor T cells with anti-Leu-8 antibody.

Authors:  M E Kanof; W Strober; S P James
Journal:  J Immunol       Date:  1987-07-01       Impact factor: 5.422

2.  Immunoregulatory function of lamina propria T cells in Crohn's disease.

Authors:  S P James; C Fiocchi; A S Graeff; W Strober
Journal:  Gastroenterology       Date:  1985-05       Impact factor: 22.682

3.  T cell-B cell regulation in the intestinal lamina propria in Crohn's disease.

Authors:  C O Elson; E Machelski; D B Weiserbs
Journal:  Gastroenterology       Date:  1985-08       Impact factor: 22.682

4.  Soluble antigen-primed inducer T cells activate antigen-specific suppressor T cells in the absence of antigen-pulsed accessory cells: phenotypic definition of suppressor-inducer and suppressor-effector cells.

Authors:  N K Damle; N Mohagheghpour; E G Engleman
Journal:  J Immunol       Date:  1984-02       Impact factor: 5.422

5.  T cell regulation of IgA immunoglobulin production in gut-associated lymphoid tissues.

Authors:  H Kawanishi; W Strober
Journal:  Mol Immunol       Date:  1983-09       Impact factor: 4.407

6.  Isolation and functional characterization of human intestinal mucosal lymphoid cells.

Authors:  D M Bull; M A Bookman
Journal:  J Clin Invest       Date:  1977-05       Impact factor: 14.808

7.  Human peripheral blood B lymphocyte subpopulations: functional and phenotypic analysis of surface IgD positive and negative subsets.

Authors:  D F Jelinek; J B Splawski; P E Lipsky
Journal:  J Immunol       Date:  1986-01       Impact factor: 5.422

8.  Requirement for three signals in B cell responses. II. Analysis of antigen- and Ia-restricted T helper cell-B cell interaction.

Authors:  R H Zubler; O Kanagawa
Journal:  J Exp Med       Date:  1982-08-01       Impact factor: 14.307
  8 in total
  1 in total

1.  Expression of T-cell receptors TcR1 (gamma/delta) and TcR2 (alpha/beta) in the human intestinal mucosa.

Authors:  L K Trejdosiewicz; C J Smart; D J Oakes; P D Howdle; G Malizia; D Campana; A W Boylston
Journal:  Immunology       Date:  1989-09       Impact factor: 7.397
  1 in total

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