Stefano Veraldi1, Ermira Cuka, Gianluca Nazzaro. 1. Department of Pathophysiology and Transplantation, University of Milan, IRCCS Foundation Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Abstract
BACKGROUND: There is no established therapy of choice for Mycobacterium marinum skin infections; clarithromycin monotherapy was used in some anecdotical cases at changeable daily doses and length. OBJECTIVE: To evaluate the efficacy and safety of pulsed clarithromycin monotherapy. METHODS: 29 patients with a clinical diagnosis of sporotrichoid fish tank granuloma were admitted from 2002 to 2013. In 14 patients, the clinical diagnosis was confirmed by history, histopathology and bacteriological examinations. All patients were treated with clarithromycin (500 mg/day for 10 consecutive days/month for 5 months). RESULTS: In 12 out of 14 patients (85.7%) complete clinical remission was recorded. Two patients showed partial remission after 3 months of therapy, but they were lost to follow-up and were therefore not considered evaluable. CONCLUSION: Our study suggests that pulsed clarithromycin monotherapy is effective and safe in sporotrichoid M. marinum skin infections.
BACKGROUND: There is no established therapy of choice for Mycobacterium marinumskin infections; clarithromycin monotherapy was used in some anecdotical cases at changeable daily doses and length. OBJECTIVE: To evaluate the efficacy and safety of pulsed clarithromycin monotherapy. METHODS: 29 patients with a clinical diagnosis of sporotrichoid fish tank granuloma were admitted from 2002 to 2013. In 14 patients, the clinical diagnosis was confirmed by history, histopathology and bacteriological examinations. All patients were treated with clarithromycin (500 mg/day for 10 consecutive days/month for 5 months). RESULTS: In 12 out of 14 patients (85.7%) complete clinical remission was recorded. Two patients showed partial remission after 3 months of therapy, but they were lost to follow-up and were therefore not considered evaluable. CONCLUSION: Our study suggests that pulsed clarithromycin monotherapy is effective and safe in sporotrichoid M. marinumskin infections.
Authors: Inge K Holden; Michala Kehrer; Aase B Andersen; Christian Wejse; Erik Svensson; Isik Somuncu Johansen Journal: Sci Rep Date: 2018-04-30 Impact factor: 4.379