Literature DB >> 25227753

Current siRNA targets in the prevention and treatment of intimal hyperplasia.

Leena Pradhan-Nabzdyk1, Chenyu Huang, Frank W LoGerfo, Christoph S Nabzdyk.   

Abstract

Intimal hyperplasia (IH) is the leading cause of late vein and prosthetic bypass graft failure. Injury at the time of graft implantation leading to the activation of endothelial cells and dedifferentiation of vascular smooth muscle cells to a synthetic phenotype are known causes of IH. Prior attempts to develop therapy to mitigate these cellular changes to prevent IH and graft failure have failed. Small interfering RNA (siRNA) mediated targeted gene silencing is a promising tool to prevent IH. Several studies have been performed in this direction to target genes that are involved in IH. In this review we discuss siRNA targets that are being investigated for prevention and treatment of IH.

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Year:  2014        PMID： 25227753      PMCID： PMC4265021     

Source DB:  PubMed          Journal:  Discov Med        ISSN： 1539-6509            Impact factor:   2.970


  57 in total

1.  Sonic hedgehog signaling induces vascular smooth muscle cell proliferation via induction of the G1 cyclin-retinoblastoma axis.

Authors:  Fenghe Li; Molly Duman-Scheel; Dong Yang; Wei Du; Jian Zhang; Chenchao Zhao; Lingfeng Qin; Shijie Xin
Journal:  Arterioscler Thromb Vasc Biol       Date:  2010-09       Impact factor: 8.311

2.  Small interfering RNA to c-myc inhibits vein graft restenosis in a rat vein graft model.

Authors:  Jun Wang; Kun Liu; Li Shen; Haiwei Wu; Hua Jing
Journal:  J Surg Res       Date:  2011-04-20       Impact factor: 2.192

3.  RNAi-mediated Rab5a suppression inhibits proliferation and migration of vascular smooth muscle cells.

Authors:  Zhigang Ma; Hao Wang; Liang Wu; Lei Zhui; Weihao Shi; Duan Ma; Zongyou Chen; Bo Yu
Journal:  Acta Cardiol       Date:  2010-10       Impact factor: 1.718

4.  Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation.

Authors:  Xue Bai; Andriana Margariti; Yanhua Hu; Yasufumi Sato; Lingfang Zeng; Aleksandar Ivetic; Ouassila Habi; Justin C Mason; Xian Wang; Qingbo Xu
Journal:  Arterioscler Thromb Vasc Biol       Date:  2010-09-30       Impact factor: 8.311

5.  Toll-like receptor 4 is involved in human and mouse vein graft remodeling, and local gene silencing reduces vein graft disease in hypercholesterolemic APOE*3Leiden mice.

Authors:  Jacco C Karper; Margreet R de Vries; Ben T van den Brand; Imo E Hoefer; Jens W Fischer; J Wouter Jukema; Hans W M Niessen; Paul H A Quax
Journal:  Arterioscler Thromb Vasc Biol       Date:  2011-02-17       Impact factor: 8.311

6.  Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia.

Authors:  Mikhail P Panchenko; Zakir Siddiquee; David M Dombkowski; Yuriy O Alekseyev; Marc E Lenburg; Jennifer D Walker; Thomas E Macgillivray; Frederic I Preffer; James R Stone
Journal:  Am J Pathol       Date:  2010-08-09       Impact factor: 4.307

7.  Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism.

Authors:  Andrew M Bakken; Clinton D Protack; Elisa Roztocil; Suzanne M Nicholl; Mark G Davies
Journal:  J Vasc Surg       Date:  2009-05       Impact factor: 4.268

8.  Static pressure drives proliferation of vascular smooth muscle cells via caveolin-1/ERK1/2 pathway.

Authors:  Di-xian Luo; Jiming Cheng; Yan Xiong; Junmo Li; Chenglai Xia; Canxin Xu; Chun Wang; Bingyang Zhu; Zhuowei Hu; Duan-fang Liao
Journal:  Biochem Biophys Res Commun       Date:  2009-12-29       Impact factor: 3.575

9.  TGF-beta through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation.

Authors:  Shirling Tsai; Scott T Hollenbeck; Evan J Ryer; Rachel Edlin; Dai Yamanouchi; Rishi Kundi; Chunjie Wang; Bo Liu; K Craig Kent
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-06-12       Impact factor: 4.733

10.  Cross-talk between angiotensin II and IGF-1-induced connexin 43 expression in human saphenous vein smooth muscle cells.

Authors:  Guanghong Jia; Anshu Aggarwal; Amanuel Yohannes; Deepak M Gangahar; Devendra K Agrawal
Journal:  J Cell Mol Med       Date:  2011-08       Impact factor: 5.310
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  3 in total

Review 1.  Vein graft failure: from pathophysiology to clinical outcomes.

Authors:  Margreet R de Vries; Karin H Simons; J Wouter Jukema; Jerry Braun; Paul H A Quax
Journal:  Nat Rev Cardiol       Date:  2016-05-19       Impact factor: 32.419

Review 2.  RNAi therapy to the wall of arteries and veins: anatomical, physiologic, and pharmacological considerations.

Authors:  Christoph S Nabzdyk; Leena Pradhan-Nabzdyk; Frank W LoGerfo
Journal:  J Transl Med       Date:  2017-07-28       Impact factor: 5.531

Review 3.  The Etiology and Molecular Mechanism Underlying Smooth Muscle Phenotype Switching in Intimal Hyperplasia of Vein Graft and the Regulatory Role of microRNAs.

Authors:  Dengshen Zhang; Yiran Cao; Daxing Liu; Jian Zhang; Yingqiang Guo
Journal:  Front Cardiovasc Med       Date:  2022-07-28
  3 in total

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