Michal Youngster1, Valerie L Ward2, Emily A Blood3, Carol E Barnewolt2, S Jean Emans4, Amy D Divasta5. 1. Division of Adolescent/Young Adult Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: michal.youngster@childrens.harvard.edu. 2. Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. 3. Division of Adolescent/Young Adult Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. 4. Division of Adolescent/Young Adult Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. 5. Division of Adolescent/Young Adult Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Division of Gynecology, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Abstract
OBJECTIVE: To determine the utility of transabdominal pelvic ultrasound in the diagnosis of polycystic ovary syndrome (PCOS) during adolescence. DESIGN: Retrospective case-control study. SETTING: Academic tertiary care pediatric hospital. PATIENT(S): A case group of 54 patients (mean age, 15.2 years) with PCOS based on the National Institutes of Health criteria and a comparison group of 98 patients (mean age, 14.6 years) with acute appendicitis. INTERVENTION(S): Transabdominal ultrasound (TAUS) images were evaluated in the two groups of adolescents, with data collected on quality of the images, ovarian volume, ovarian follicle count, and endometrial thickness. MAIN OUTCOME MEASURE(S): Sonographic modified Rotterdam criteria (volume>10 mL and/or follicle number per section≥10) for polycystic ovaries (PCO). RESULT(S): Among the 54 patients with PCOS and 98 comparison subjects with usable images, the sonographic modified Rotterdam criteria for PCO morphology (PCOM) were met more frequently in the PCOS group than in the comparison group (65% vs. 11%). The vast majority of images were of adequate quality for diagnosis (PCOS=94% and comparison=91%), even in the presence of obesity. CONCLUSION(S): The prevalence of ovarian morphology meeting the sonographic modified Rotterdam criteria by TAUS in girls with PCOS was markedly higher than in the adolescents serving as a comparison group. PCOM findings by the sonographic modified Rotterdam criteria were uncommon in the nongynecologic comparison group, in contrast to previous reports. TAUS may provide useful information in the evaluation of PCOS during adolescence, even in obese adolescents.
OBJECTIVE: To determine the utility of transabdominal pelvic ultrasound in the diagnosis of polycystic ovary syndrome (PCOS) during adolescence. DESIGN: Retrospective case-control study. SETTING: Academic tertiary care pediatric hospital. PATIENT(S): A case group of 54 patients (mean age, 15.2 years) with PCOS based on the National Institutes of Health criteria and a comparison group of 98 patients (mean age, 14.6 years) with acute appendicitis. INTERVENTION(S): Transabdominal ultrasound (TAUS) images were evaluated in the two groups of adolescents, with data collected on quality of the images, ovarian volume, ovarian follicle count, and endometrial thickness. MAIN OUTCOME MEASURE(S): Sonographic modified Rotterdam criteria (volume>10 mL and/or follicle number per section≥10) for polycystic ovaries (PCO). RESULT(S): Among the 54 patients with PCOS and 98 comparison subjects with usable images, the sonographic modified Rotterdam criteria for PCO morphology (PCOM) were met more frequently in the PCOS group than in the comparison group (65% vs. 11%). The vast majority of images were of adequate quality for diagnosis (PCOS=94% and comparison=91%), even in the presence of obesity. CONCLUSION(S): The prevalence of ovarian morphology meeting the sonographic modified Rotterdam criteria by TAUS in girls with PCOS was markedly higher than in the adolescents serving as a comparison group. PCOM findings by the sonographic modified Rotterdam criteria were uncommon in the nongynecologic comparison group, in contrast to previous reports. TAUS may provide useful information in the evaluation of PCOS during adolescence, even in obese adolescents.
Authors: E Gourgari; M Lodish; R Shamburek; M Keil; R Wesley; M Walter; M Sampson; S Bernstein; D Khurana; C Lyssikatos; S Ten; A Dobs; A T Remaley; C A Stratakis Journal: J Clin Endocrinol Metab Date: 2015-09-15 Impact factor: 5.958
Authors: Lisa E Kenigsberg; Chhavi Agarwal; Sanghun Sin; Keivan Shifteh; Carmen R Isasi; Rebecca Crespi; Janeta Ivanova; Susan M Coupey; Rubina A Heptulla; Raanan Arens Journal: Fertil Steril Date: 2015-09-03 Impact factor: 7.329
Authors: Jee Young Jeong; Min Kyoung Kim; Inha Lee; Jisun Yun; Young Bin Won; Bo Hyon Yun; Seok Kyo Seo; SiHyun Cho; Young Sik Choi; Byung Seok Lee Journal: Obstet Gynecol Sci Date: 2019-07-22