| Literature DB >> 25226228 |
Naoto Kojima1, Tetsuya Fushimi2, Takahiro Tatsukawa2, Tetsuaki Tanaka2, Mutsumi Okamura3, Akinobu Akatsuka3, Takao Yamori3, Shingo Dan3, Hiroki Iwasaki4, Masayuki Yamashita4.
Abstract
Five novel acetogenin analogues with a furan, thiophene, or thiazole ring were synthesized, and their inhibitory activities toward human cancer cell lines were evaluated. The analogues showed more potent activities than natural acetogenin. One of them, the thiophene-3-carboxamide analogue, strongly inhibited the growth of human lung cancer cell line NCI-H23 in the xenograft mouse assay without critical toxicity.Entities:
Keywords: Annonaceous acetogenin; Antitumor activity; Chemical synthesis; Structure–activity relationship
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Year: 2014 PMID： 25226228 DOI： 10.1016/j.ejmech.2014.09.026
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514