Hanna Cho1, Seun Jeon2, Changsoo Kim3, Byoung Seok Ye4, Geon Ha Kim5, Young Noh6, Hee Jin Kim1, Cindy W Yoon7, Yeo Jin Kim1, Jung-Hyun Kim1, Sang Eon Park1, Sung Tae Kim8, Jong-Min Lee2, Sue J Kang1, Mee Kyung Suh1, Juhee Chin1, Duk L Na1, Dae Ryong Kang9, Sang Won Seo1. 1. Department of Neurology,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul,South Korea. 2. Department of Biomedical Engineering,Hanyang University,Seoul,South Korea. 3. Department of Preventive Medicine and the Institute for Environmental Research. 4. Department of Neurology,Yonsei University College of Medicine,Seoul,South Korea. 5. Department of Neurology,Ewha Womans University Mokdong Hospital,Ewha Womans University School of Medicine,Seoul,South Korea. 6. Department of Neurology,Gachon University Gil Medical Center,Incheon,South Korea. 7. Department of Neurology,Inha University School of Medicine,Incheon,South Korea. 8. Department of Radiology,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul,South Korea. 9. Biostatics of Collaboration Unit,Yonsei University College of Medicine,Seoul,South Korea.
Abstract
BACKGROUND: Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between AD patients with HE (HE-AD) and AD patients with LE (LE-AD). METHODS: We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years). RESULTS: As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD. CONCLUSION: Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis.
BACKGROUND: Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between ADpatients with HE (HE-AD) and ADpatients with LE (LE-AD). METHODS: We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years). RESULTS: As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD. CONCLUSION: Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in ADpatients over time, which underlines the importance of education level for predicting prognosis.
Authors: Juyoun Lee; Hanna Cho; Seun Jeon; Hee Jin Kim; Yeo Jin Kim; Jeongmin Lee; Sung Tae Kim; Jong-Min Lee; Juhee Chin; Samuel N Lockhart; Ae Young Lee; Duk L Na; Sang Won Seo Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Na-Yeon Jung; Hanna Cho; Yeo Jin Kim; Hee Jin Kim; Jong Min Lee; Seongbeom Park; Sung Tae Kim; Eun-Joo Kim; Jae Seung Kim; Seung Hwan Moon; Jae-Hong Lee; Michael Ewers; Duk L Na; Sang Won Seo Journal: Alzheimers Res Ther Date: 2018-09-27 Impact factor: 6.982