Martin Doerler1, Sabine Eming, Joachim Dissemond, Anneke Wolter, Maren Stoffels-Weindorf, Stefanie Reich-Schupke, Peter Altmeyer, Markus Stücker. 1. Martin Doerler, MD, is a Dermatology Consultant at the Vein Center, Departments of Dermatology and Vascular Surgery, at Ruhr-University Bochum, Germany. Sabine Eming, MD, is a Professor in the Department of Dermatology at the University of Cologne, Germany. Joachim Dissemond, MD, is a Professor in the Department of Dermatology at the University of Essen, Germany. Anneke Wolter, MD, is a Resident in the Department of Dermatology at the University of Cologne, Germany. Maren Stoffels-Weindorf, MD, is a Resident in the Department of Dermatology at the University of Essen, Germany. Stefanie Reich-Schupke, MD, is the Department Head of the Competence Center for Phlebology and Dermatology, Artemed-Fachklinik Prof. Dr. Dr. Salfeld GmbH & Co. KG, Bad Oeynhausen, Germany. Peter Altmeyer, MD, is the Chief Physician and Professor of Dermatology in the Department of Dermatology, Venereology, and Allergology at Ruhr-University Bochum, Germany. Markus Stücker, MD, is a Professor at the Vein Center in the Departments of Dermatology and Vascular Surgery at Ruhr-University Bochum, Germany.
Abstract
OBJECTIVE: To evaluate the efficacy, tolerability, and safety of a novel wound dressing containing epidermal growth factor (EGF) in a collagen-gel matrix on hard-to-heal venous leg ulcers. PATIENTS AND METHODS: The authors included 33 hard-to-heal venous leg ulcers found on 31 patients. The EGF-containing dressing was applied 3 times while best practice conservative wound treatment was continued. Patients were followed up with after 1, 2, and 3 months to evaluate (a) the wound size, (b) the ease of application and dissolution of the dressing, and (c) the wound dressing by means of a scale ranging from 1 to 5 (1 = best, 5 = worst). RESULTS: The protocol was completed by 25 of 31 patients. The reasons for discontinuation were wound infection, pain, and lost to follow-up (n = 2 each, respectively). After 3 months, the average wound surface was significantly reduced (from 33.69 cm to 18.94 cm, P = .023). On a scale from 0 to 100, the wound dressing was evaluated as very easy to apply and highly dissolvable (mean value of 97.14 and 98.11, respectively; 100 = very easy to apply or 100% dissolution). The dressing was generally well tolerated and scored a mean overall rating of 2.16 by healthcare specialists and 2.40 by patients. CONCLUSION: The authors' results demonstrate that the novel EGF-containing wound dressing was generally well tolerated and safe. Combined with the significant wound surface reduction, it can be regarded as an adequate novel treatment option for patients with hard-to-heal venous leg ulcers.
OBJECTIVE: To evaluate the efficacy, tolerability, and safety of a novel wound dressing containing epidermal growth factor (EGF) in a collagen-gel matrix on hard-to-heal venous leg ulcers. PATIENTS AND METHODS: The authors included 33 hard-to-heal venous leg ulcers found on 31 patients. The EGF-containing dressing was applied 3 times while best practice conservative wound treatment was continued. Patients were followed up with after 1, 2, and 3 months to evaluate (a) the wound size, (b) the ease of application and dissolution of the dressing, and (c) the wound dressing by means of a scale ranging from 1 to 5 (1 = best, 5 = worst). RESULTS: The protocol was completed by 25 of 31 patients. The reasons for discontinuation were wound infection, pain, and lost to follow-up (n = 2 each, respectively). After 3 months, the average wound surface was significantly reduced (from 33.69 cm to 18.94 cm, P = .023). On a scale from 0 to 100, the wound dressing was evaluated as very easy to apply and highly dissolvable (mean value of 97.14 and 98.11, respectively; 100 = very easy to apply or 100% dissolution). The dressing was generally well tolerated and scored a mean overall rating of 2.16 by healthcare specialists and 2.40 by patients. CONCLUSION: The authors' results demonstrate that the novel EGF-containing wound dressing was generally well tolerated and safe. Combined with the significant wound surface reduction, it can be regarded as an adequate novel treatment option for patients with hard-to-heal venous leg ulcers.
Authors: Mireille A Boink; Sanne Roffel; Kamran Nazmi; Jan G M Bolscher; Enno C I Veerman; Susan Gibbs Journal: J Immunol Res Date: 2017-07-26 Impact factor: 4.818