Depression is one of the most disabling medical conditions in the world today, yet its etiologies remain unclear and current treatments are not wholly effective. Animal models are a powerful tool to investigate possible causes and treatments for human diseases. We describe an animal model of social defeat as a possible model for human depression. We discuss the paradigm, behavioral correlates to depression, and potential underlying neurobiological mechanisms with an eye toward possible future therapies.
Depression is one of the most disabling medical conditions in the world today, yet its etiologies remain unclear and current treatments are not wholly effective. Animal models are a powerful tool to investigate possible causes and treatments for human diseases. We describe an animal model of social defeat as a possible model for humandepression. We discuss the paradigm, behavioral correlates to depression, and potential underlying neurobiological mechanisms with an eye toward possible future therapies.
Authors: Katharine E McCann; Anna M Rosenhauer; Genna M F Jones; Alisa Norvelle; Dennis C Choi; Kim L Huhman Journal: Psychoneuroendocrinology Date: 2016-10-26 Impact factor: 4.905
Authors: Katharine E McCann; David M Sinkiewicz; Anna M Rosenhauer; Linda Q Beach; Kim L Huhman Journal: Mol Neurobiol Date: 2018-09-08 Impact factor: 5.590
Authors: Anna M Rosenhauer; Linda Q Beach; Elizabeth C Jeffress; Brittany M Thompson; Katharine E McCann; Katherine A Partrick; Bryan Diaz; Alisa Norvelle; Dennis C Choi; Kim L Huhman Journal: Neuropharmacology Date: 2018-12-14 Impact factor: 5.250
Authors: Andre Der-Avakian; Manoranjan S D'Souza; David N Potter; Elena H Chartoff; William A Carlezon; Diego A Pizzagalli; Athina Markou Journal: Psychopharmacology (Berl) Date: 2017-03-09 Impact factor: 4.530