Literature DB >> 25225184

The kidney research national dialogue: gearing up to move forward.

Joseph V Bonventre1, L Ebony Boulware1, Laura M Dember1, Barry I Freedman1, Susan L Furth1, Lawrence B Holzman1, Christian J Ketchum1, Melissa H Little1, Rajnish Mehrotra1, Sharon M Moe1, Jeff M Sands1, John R Sedor1, Stefan Somlo1, Robert A Star1, Krystyna E Rys-Sikora2.   

Abstract

The National Institute of Diabetes and Digestive and Kidney Diseases-supported Kidney Research National Dialogue asked the scientific community to formulate and prioritize research objectives that would improve our understanding of kidney function and disease; >1600 participants from >30 countries posted >300 ideas and >500 comments covering all areas of kidney research. Smaller groups of investigators interrogated the postings and published a series of commentaries in CJASN. Additional review of the entire series identified six cross-cutting themes: (1) increase training and team science opportunities to maintain/expand the nephrology workforce, (2) develop novel technologies to assess kidney function, (3) promote human discovery research to better understand normal and diseased kidney function, (4) establish integrative models of kidney function to inform diagnostic and treatment strategies, (5) promote interventional studies that incorporate more responsive outcomes and improved trial designs, and (6) foster translation from clinical investigation to community implementation. Together, these cross-cutting themes provide a research plan to better understand normal kidney biology and improve the prevention, diagnosis, and treatment of kidney disease, and as such, they will inform future research efforts supported by the National Institute of Diabetes and Digestive and Kidney Diseases through workshops and initiatives.
Copyright © 2014 by the American Society of Nephrology.

Entities:  

Keywords:  AKI; bioinformatics; biomarkers; systems medicine; training

Mesh:

Year:  2014        PMID: 25225184      PMCID: PMC4186514          DOI: 10.2215/CJN.07310714

Source DB:  PubMed          Journal:  Clin J Am Soc Nephrol        ISSN: 1555-9041            Impact factor:   8.237


  12 in total

1.  Defining kidney biology to understand renal disease.

Authors:  Melissa H Little; Dennis Brown; Benjamin D Humphreys; Andrew P McMahon; Jeffrey H Miner; Jeff M Sands; Ora A Weisz; Chris Mullins; Deborah Hoshizaki
Journal:  Clin J Am Soc Nephrol       Date:  2013-12-26       Impact factor: 8.237

2.  Pediatric kidney disease: tracking onset and improving clinical outcomes.

Authors:  Carlton M Bates; Jennifer R Charlton; Maria E Ferris; Friedhelm Hildebrandt; Deborah K Hoshizaki; Bradley A Warady; Marva M Moxey-Mims
Journal:  Clin J Am Soc Nephrol       Date:  2014-03-20       Impact factor: 8.237

3.  Dialysis therapies: a National Dialogue.

Authors:  Rajnish Mehrotra; Anil Agarwal; Joanne M Bargman; Jonathan Himmelfarb; Kirsten L Johansen; Suzanne Watnick; Jack Work; Kevin McBryde; Michael Flessner; Paul L Kimmel
Journal:  Clin J Am Soc Nephrol       Date:  2014-01-23       Impact factor: 8.237

4.  The last mile: translational research to improve CKD outcomes.

Authors:  Delphine S Tuot; Clarissa Jonas Diamantidis; Cynthia F Corbett; L Ebony Boulware; Chester H Fox; Donna H Harwood; Robert A Star; Krystyna E Rys-Sikora; Andrew Narva
Journal:  Clin J Am Soc Nephrol       Date:  2014-06-26       Impact factor: 8.237

5.  Propagating the nephrology research workforce: a Kidney Research National Dialogue training commentary.

Authors:  Donald E Kohan; Mark G Parker; Susan L Furth; Billy G Hudson; Karen M Warburton; Krystyna E Rys-Sikora; Tracy L Rankin
Journal:  Clin J Am Soc Nephrol       Date:  2014-03-13       Impact factor: 8.237

6.  Rescuing US biomedical research from its systemic flaws.

Authors:  Bruce Alberts; Marc W Kirschner; Shirley Tilghman; Harold Varmus
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-14       Impact factor: 11.205

7.  AKI: a path forward.

Authors:  Joseph V Bonventre; David Basile; Kathleen D Liu; Dianne McKay; Bruce A Molitoris; Karl A Nath; Thomas L Nickolas; Mark D Okusa; Paul M Palevsky; Rick Schnellmann; Krystyna Rys-Sikora; Paul L Kimmel; Robert A Star
Journal:  Clin J Am Soc Nephrol       Date:  2013-07-18       Impact factor: 8.237

8.  Glomerular disease: looking beyond pathology.

Authors:  Roger C Wiggins; Charles E Alpers; Lawrence B Holzman; John C He; David J Salant; Sumant S Chugh; Rama Natarajan; Howard Trachtman; Lauren Brasile; Robert A Star; Krystyna E Rys-Sikora; Marva M Moxey-Mims; Michael F Flessner
Journal:  Clin J Am Soc Nephrol       Date:  2014-04-03       Impact factor: 8.237

9.  Diabetic nephropathy: a national dialogue.

Authors:  Matthew D Breyer; Thomas M Coffman; Michael F Flessner; Linda F Fried; Raymond C Harris; Christian J Ketchum; Matthias Kretzler; Robert G Nelson; John R Sedor; Katalin Susztak
Journal:  Clin J Am Soc Nephrol       Date:  2013-06-20       Impact factor: 8.237

Review 10.  Kidney research national dialogue overview and commentary.

Authors:  Krystyna E Rys-Sikora; Christian J Ketchum; Robert A Star
Journal:  Clin J Am Soc Nephrol       Date:  2013-06-20       Impact factor: 8.237

View more
  10 in total

1.  Understanding renal physiology leads to therapeutic advances in renal disease.

Authors:  Jeff M Sands
Journal:  Physiology (Bethesda)       Date:  2015-05

Review 2.  Biomarkers for the Early Detection and Prognosis of Acute Kidney Injury.

Authors:  Rakesh Malhotra; Edward D Siew
Journal:  Clin J Am Soc Nephrol       Date:  2016-11-08       Impact factor: 8.237

3.  Complementary Initiatives from the NIDDK to Advance Kidney Health.

Authors:  Jenna M Norton; Christian J Ketchum; Andrew S Narva; Robert A Star; Griffin P Rodgers
Journal:  Clin J Am Soc Nephrol       Date:  2017-07-17       Impact factor: 8.237

4.  A Rebuttal to "The CKD Classification System in the Precision Medicine Era".

Authors:  Andrew S Levey; Adeera Levin
Journal:  Clin J Am Soc Nephrol       Date:  2017-08-07       Impact factor: 8.237

Review 5.  Phenotyping of Acute Kidney Injury: Beyond Serum Creatinine.

Authors:  Dennis G Moledina; Chirag R Parikh
Journal:  Semin Nephrol       Date:  2018-01       Impact factor: 5.299

6.  Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry.

Authors:  Nikhil Singh; Zachary M Avigan; Judith A Kliegel; Brian M Shuch; Ruth R Montgomery; Gilbert W Moeckel; Lloyd G Cantley
Journal:  JCI Insight       Date:  2019-06-20

Review 7.  The proximal tubule is the primary target of injury and progression of kidney disease: role of the glomerulotubular junction.

Authors:  Robert L Chevalier
Journal:  Am J Physiol Renal Physiol       Date:  2016-05-18

8.  Advancing American Kidney Health (AAKH): Catalyst for Investment in Kidney Diseases Clinical Trials and Precision Medicine: An Opportunity to Advance Upstream Interventions and the Importance of Nephrology.

Authors:  Kevin John Fowler
Journal:  Clin J Am Soc Nephrol       Date:  2020-08-05       Impact factor: 8.237

Review 9.  Roadblocks and Opportunities to the Implementation of Novel Therapies for Acute Kidney Injury: A Narrative Review.

Authors:  Paraish S Misra; Vanessa Silva E Silva; David Collister
Journal:  Can J Kidney Health Dis       Date:  2019-10-09

10.  Risk of percutaneous renal biopsy of native kidneys in the evaluation of acute kidney injury.

Authors:  Stephen M Korbet; Casey N Gashti; Joni K Evans; William L Whittier
Journal:  Clin Kidney J       Date:  2018-07-02
  10 in total

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