K M Olszowy1, J Lavelle1, K Rachfal1, S Hempstead1, K Drouin2, J M Darcy1, C Reiber3, R M Garruto4. 1. Department of Anthropology, SUNY Binghamton, Binghamton, NY, USA; Laboratory of Biomedical Anthropology and Neuroscience, SUNY Binghamton, Binghamton, NY, USA. 2. Department of Anthropology, SUNY Binghamton, Binghamton, NY, USA; Laboratory of Biomedical Anthropology and Neuroscience, SUNY Binghamton, Binghamton, NY, USA; Biospecimen Archive Facility, SUNY Binghamton, Binghamton, NY, USA. 3. Department of Anthropology, SUNY Binghamton, Binghamton, NY, USA. 4. Department of Anthropology, SUNY Binghamton, Binghamton, NY, USA; Laboratory of Biomedical Anthropology and Neuroscience, SUNY Binghamton, Binghamton, NY, USA; Biospecimen Archive Facility, SUNY Binghamton, Binghamton, NY, USA. Electronic address: rgarruto@binghamton.edu.
Abstract
OBJECTIVES: It is currently unknown whether chronic wasting disease (CWD), a transmissible spongiform encephalopathy of cervids, is transmissible to humans. Reported on here are the behavioural risk factors and health conditions associated with a six-year follow-up of a known point-source exposure to a CWD infected deer in an Upstate New York community. STUDY DESIGN: Longitudinal. METHODS: The Oneida County Chronic Wasting Disease Surveillance Project was launched in 2005 in response to a point-source exposure to a CWD infected deer at a March 2005 Sportsmen's feast in Upstate New York. Eighty-one exposed individuals participated in the 2005 baseline data collection, and were sent follow-up questionnaires following each deer hunting season between 2005 and 2011. RESULTS: Over a six year period, participants reported a reduction in overall venison consumption. Participants reported no significant changes in health conditions, although several conditions (vision loss, heart disease, type 2 diabetes, weight changes, hypertension, and arthritis), were significantly associated with age. CONCLUSIONS: To this day, this incident remains the only known large-scale point-source exposure to a CWD infected deer. Prion diseases can incubate for multiple decades before the manifestation of clinical symptoms; thus, continued surveillance of this exposed study population represents a unique opportunity to assess the risk of CWD transmission to humans. This project is uniquely situated to provide the first epidemiological evidence of CWD transmission to humans, should it occur.
OBJECTIVES: It is currently unknown whether chronic wasting disease (CWD), a transmissible spongiform encephalopathy of cervids, is transmissible to humans. Reported on here are the behavioural risk factors and health conditions associated with a six-year follow-up of a known point-source exposure to a CWD infected deer in an Upstate New York community. STUDY DESIGN: Longitudinal. METHODS: The Oneida County Chronic Wasting Disease Surveillance Project was launched in 2005 in response to a point-source exposure to a CWD infected deer at a March 2005 Sportsmen's feast in Upstate New York. Eighty-one exposed individuals participated in the 2005 baseline data collection, and were sent follow-up questionnaires following each deer hunting season between 2005 and 2011. RESULTS: Over a six year period, participants reported a reduction in overall venison consumption. Participants reported no significant changes in health conditions, although several conditions (vision loss, heart disease, type 2 diabetes, weight changes, hypertension, and arthritis), were significantly associated with age. CONCLUSIONS: To this day, this incident remains the only known large-scale point-source exposure to a CWD infected deer. Prion diseases can incubate for multiple decades before the manifestation of clinical symptoms; thus, continued surveillance of this exposed study population represents a unique opportunity to assess the risk of CWD transmission to humans. This project is uniquely situated to provide the first epidemiological evidence of CWD transmission to humans, should it occur.
Authors: Luis E Escobar; Sandra Pritzkow; Steven N Winter; Daniel A Grear; Megan S Kirchgessner; Ernesto Dominguez-Villegas; Gustavo Machado; A Townsend Peterson; Claudio Soto Journal: Biol Rev Camb Philos Soc Date: 2019-11-21