Woon-Seok Kang1, Seong-Hyop Kim2, Sung Yun Kim3, Chung-Sik Oh3, Song-Am Lee4, Jun-Seok Kim4. 1. Department of Anesthesiology and Pain Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea; Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea. 2. Department of Anesthesiology and Pain Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea; Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea. Electronic address: yshkim75@daum.net. 3. Department of Anesthesiology and Pain Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. 4. Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea; Department of Thoracic and Cardiovascular Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
Abstract
OBJECTIVES: Measurements of stroke volume variation for volume management in mechanically ventilated patients are influenced by various factors, such as tidal volume, respiratory rate, and chest/lung compliance. However, research regarding the effect of positive end-expiratory pressure on stroke volume variation is limited. METHODS: Patients were divided into responder and nonresponder groups according to the prediction of fluid response by the passive leg raising test and hemodynamic parameters, including stroke volume variation, measured in all patients at the following ventilator settings: (1) conventional ventilation (C), tidal volume 10 mL · kg(-1) with positive end-expiratory pressure settings of 0 (C0), 5 (C5), and 10 cmH2O (C10) and (2) lung protective ventilation (P), tidal volume 6 mL · kg(-1) with positive end-expiratory pressure settings of 0 (P0), 5 (P5), and 10 cmH2O (P10). RESULTS: Regardless of ventilator setting, stroke volume variation in the responder group had an increasing trend as increased positive end-expiratory pressure level and was significantly higher than in the nonresponder group at each positive end-expiratory pressure level. The area under the curve was (1) 0.899 at C0, 0.942 at C5, and 0.985 at C10; and (2) 0.901 at P0, 0.932 at P5, and 0.947 at P10. Optimal threshold values given by receiver operating characteristic curve analysis were (1) 13.5%, 13.5%, and 14.5%; and (2) 13.5%, 13.5%, and 14.5%, respectively. CONCLUSIONS: The threshold value of stroke volume variation in predicting fluid responsiveness may change when positive end-expiratory pressure 10 cmH2O is applied. This must be considered when stroke volume variation is used to detect the fluid responsiveness to prevent volume overload in this mechanical ventilation setting.
OBJECTIVES: Measurements of stroke volume variation for volume management in mechanically ventilated patients are influenced by various factors, such as tidal volume, respiratory rate, and chest/lung compliance. However, research regarding the effect of positive end-expiratory pressure on stroke volume variation is limited. METHODS:Patients were divided into responder and nonresponder groups according to the prediction of fluid response by the passive leg raising test and hemodynamic parameters, including stroke volume variation, measured in all patients at the following ventilator settings: (1) conventional ventilation (C), tidal volume 10 mL · kg(-1) with positive end-expiratory pressure settings of 0 (C0), 5 (C5), and 10 cmH2O (C10) and (2) lung protective ventilation (P), tidal volume 6 mL · kg(-1) with positive end-expiratory pressure settings of 0 (P0), 5 (P5), and 10 cmH2O (P10). RESULTS: Regardless of ventilator setting, stroke volume variation in the responder group had an increasing trend as increased positive end-expiratory pressure level and was significantly higher than in the nonresponder group at each positive end-expiratory pressure level. The area under the curve was (1) 0.899 at C0, 0.942 at C5, and 0.985 at C10; and (2) 0.901 at P0, 0.932 at P5, and 0.947 at P10. Optimal threshold values given by receiver operating characteristic curve analysis were (1) 13.5%, 13.5%, and 14.5%; and (2) 13.5%, 13.5%, and 14.5%, respectively. CONCLUSIONS: The threshold value of stroke volume variation in predicting fluid responsiveness may change when positive end-expiratory pressure 10 cmH2O is applied. This must be considered when stroke volume variation is used to detect the fluid responsiveness to prevent volume overload in this mechanical ventilation setting.
Authors: Jorge Iván Alvarado Sánchez; Juan Daniel Caicedo Ruiz; Juan José Diaztagle Fernández; William Fernando Amaya Zuñiga; Gustavo Adolfo Ospina-Tascón; Luis Eduardo Cruz Martínez Journal: Ann Intensive Care Date: 2021-02-08 Impact factor: 6.925
Authors: Christoph Karl Hofer; Martin Geisen; Sonja Hartnack; Omer Dzemali; Michael Thomas Ganter; Andreas Zollinger Journal: Turk J Anaesthesiol Reanim Date: 2018-04-01