Literature DB >> 2522332

Role of endoperoxides in arachidonic acid-induced vasoconstriction in the isolated perfused kidney of the rat.

J Quilley1, J C McGiff, A Nasjletti.   

Abstract

1. Administration of arachidonic acid caused dose-dependent vasoconstriction in the isolated rat kidney perfused in situ with Krebs-Henseleit solution. 2. Inhibition of cyclo-oxygenase with indomethacin or meclofenamate reduced the renal vasoconstrictor effect of arachidonic acid. 3. The renal vasoconstrictor effect of arachidonic acid was unaffected by CGS-13080 at concentrations that effectively reduced thromboxane A2 (TxA2) synthesis by platelets and the kidney. 4. The endoperoxide/TxA2 receptor antagonist, SQ 29,548, abolished the renal vasoconstrictor effect of arachidonic acid and of U46619, an endoperoxide analogue. In contrast, SQ 29,548 did not affect the renal vasoconstrictor response to angiotensin II, prostaglandin E2 or F2 alpha. 5. These data suggest that the vasoconstrictor effect of arachidonic acid in the isolated kidney of the rat is mediated by its metabolites, including the prostaglandin endoperoxides.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2522332      PMCID： PMC1854306          DOI： 10.1111/j.1476-5381.1989.tb11790.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  14 in total

1.  Thromboxane A2 and prostaglandin endoperoxide receptors in platelets and vascular smooth muscle.

Authors:  D L Saussy; D E Mais; D R Knapp; P V Halushka
Journal:  Circulation       Date:  1985-12       Impact factor: 29.690

2.  The effects of a new thromboxane synthetase inhibitor, CGS-13080, in man.

Authors:  M W MacNab; E L Foltz; B S Graves; R K Rinehart; S L Tripp; N R Feliciano; S Sen
Journal:  J Clin Pharmacol       Date:  1984 Feb-Mar       Impact factor: 3.126

3.  Mechanism of arachidonic acid-induced vasoconstriction in the intact rat kidney: possible involvement of thromboxane A2.

Authors:  H M Sakr; E W Dunham
Journal:  J Pharmacol Exp Ther       Date:  1982-06       Impact factor: 4.030

4.  Drugs which inhibit prostaglandin biosynthesis.

Authors:  R J Flower
Journal:  Pharmacol Rev       Date:  1974-03       Impact factor: 25.468

5.  Modulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat kidney.

Authors:  K U Malik; J C McGiff
Journal:  Circ Res       Date:  1975-05       Impact factor: 17.367

6.  The pharmacological profile of the thromboxane A2 antagonist BM 13.177. A new anti-platelet and anti-thrombotic drug.

Authors:  K Stegmeier; J Pill; B Müller-Beckmann; F H Schmidt; E C Witte; H P Wolff; H Patscheke
Journal:  Thromb Res       Date:  1984-08-15       Impact factor: 3.944

7.  Enhanced renal prostaglandin production in the dog. II. Effects on intrarenal hemodynamics.

Authors:  L C Chang; J A Splawinski; J A Oates; A S Nies
Journal:  Circ Res       Date:  1975-01       Impact factor: 17.367

8.  Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations.

Authors:  R A Coleman; P P Humphrey; I Kennedy; G P Levy; P Lumley
Journal:  Br J Pharmacol       Date:  1981-07       Impact factor: 8.739

9.  Pulmonary vascular response to thrombin: effects of thromboxane synthetase inhibition with OKY-046 and OKY-1581.

Authors:  R Garcia-Szabo; D F Kern; A B Malik
Journal:  Prostaglandins       Date:  1984-12

10.  Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist.

Authors:  M L Ogletree; D N Harris; R Greenberg; M F Haslanger; M Nakane
Journal:  J Pharmacol Exp Ther       Date:  1985-08       Impact factor: 4.030
View more
  9 in total

1.  Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats.

Authors:  A Turull; C Piera; J Queralt
Journal:  Inflammation       Date:  2001-04       Impact factor: 4.092

2.  Effects of indomethacin on the regional haemodynamic responses to low doses of endothelins and sarafotoxin.

Authors:  S M Gardiner; A M Compton; T Bennett
Journal:  Br J Pharmacol       Date:  1990-05       Impact factor: 8.739

3.  Renal protective effect of chronic inhibition of COX-2 with SC-58236 in streptozotocin-diabetic rats.

Authors:  J Quilley; M Santos; P Pedraza
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-03-25       Impact factor: 4.733

4.  Mediation of bradykinin-induced contraction in canine veins via thromboxane/prostaglandin endoperoxide receptor activation.

Authors:  M O Aksoy; C Harakal; J B Smith; G J Stewart; C R Zerweck
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

5.  Renal vascular responsiveness to arachidonic acid in experimental diabetes.

Authors:  J Quilley; J C McGiff
Journal:  Br J Pharmacol       Date:  1990-06       Impact factor: 8.739

6.  Proceedings of the British Pharmacological Society. Leeds, 12th-14th July 1989. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

7.  Role of superoxide and thromboxane receptors in acute angiotensin II-induced vasoconstriction of rabbit vessels.

Authors:  Sandra L Pfister; Kasem Nithipatikom; William B Campbell
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-04-01       Impact factor: 4.733

8.  Regional haemodynamic responses to acetylcholine, methoxamine, salbutamol and bradykinin during lipopolysaccharide infusion in conscious rats.

Authors:  J Waller; S M Gardiner; T Bennett
Journal:  Br J Pharmacol       Date:  1994-08       Impact factor: 8.739

9.  A Thromboxane A2 Receptor-Driven COX-2-Dependent Feedback Loop That Affects Endothelial Homeostasis and Angiogenesis.

Authors:  Robert Eckenstaler; Anne Ripperger; Michael Hauke; Markus Petermann; Sandra A Hemkemeyer; Edzard Schwedhelm; Süleyman Ergün; Maike Frye; Oliver Werz; Andreas Koeberle; Heike Braun; Ralf A Benndorf
Journal:  Arterioscler Thromb Vasc Biol       Date:  2022-03-03       Impact factor: 8.311
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.