Literature DB >> 25222306

Elevated aspartate aminotransferase-to-platelet ratio index in perinatally HIV-infected children in the United States.

George K Siberry1, Kunjal Patel, Jorge A Pinto, Ana Puga, Ayesha Mirza, Tracie L Miller, Russell B Van Dyke.   

Abstract

Elevated aspartate aminotransferase-to-platelet ratio index may signal liver fibrosis. Among 397 US children with perinatal HIV infection, at baseline was >1.5 in 0.8% [95% confidence interval (CI), 0.2-2.2%) and >0.5 in 6.5% (95% CI, 4.3-9.4%); incidence on study was 0.5 (95% CI, 0.2-1.2) and 6.4 (95% CI, 4.8-8.3) per 100 person-years, respectively. Long-term liver outcomes after perinatal HIV infection warrant further study.

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Year:  2014        PMID： 25222306      PMCID： PMC4166595          DOI： 10.1097/INF.0000000000000348

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN： 0891-3668            Impact factor:   2.129


  13 in total

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4.  Performance of the AST-to-platelet ratio index as a noninvasive marker of fibrosis in pediatric patients with chronic viral hepatitis.

Authors:  Katherine E McGoogan; P Brian Smith; Steve S Choi; Wallace Berman; Ravi Jhaveri
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5.  HIV monoinfection is associated with increased aspartate aminotransferase-to-platelet ratio index, a surrogate marker for hepatic fibrosis.

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Review 6.  Liver disease in the HIV-infected individual.

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  7 in total

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5.  Liver fibrosis progression in a cohort of young HIV and HIV/ HBV co-infected patients: A longitudinal study using non-invasive APRI and Fib-4 scores.

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7.  The physical and psychological effects of HIV infection and its treatment on perinatally HIV-infected children.

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  7 in total

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