Literature DB >> 25222040

Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids.

You-Min Ying1, Wei-Guang Shan, Zha-Jun Zhan.   

Abstract

Biotransformation of huperzine A (hupA) by a fungal endophyte, Ceriporia lacerate HS-ZJUT-C13A, afforded compounds 1-5 and three tremulane sesquiterpenoids, 6-8. Huptremules A-D (1-4) feature unusual sesquiterpenoid-alkaloid hybrid structures that integrate the characteristics of fungal metabolites (tremulane sesquiterpenoids) and the exogenous substrate (hupA). These results support the use of fungal endophytes as biocatalysts for the biotransformation of natural products, particularly those originating from the host plant.

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Year:  2014        PMID： 25222040     DOI： 10.1021/np500412f

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

1.  Pyrrole 2-carbaldehyde derived alkaloids from the roots of Angelica dahurica.

Authors:  Bowen Qi; Wanqing Yang; Ning Ding; Yuan Luo; Fangfang Jia; Xiao Liu; Juan Wang; Xiaohui Wang; Pengfei Tu; Shepo Shi
Journal:  J Nat Med       Date:  2019-06-17       Impact factor: 2.343

2.  Whole-Genome Sequencing and Analysis of the White-Rot Fungus Ceriporia lacerata Reveals Its Phylogenetic Status and the Genetic Basis of Lignocellulose Degradation and Terpenoid Synthesis.

Authors:  Zhitao Mao; Ping Yang; Huanhuan Liu; Yufeng Mao; Yu Lei; Dongwei Hou; Hongwu Ma; Xiaoping Liao; Wenxia Jiang
Journal:  Front Microbiol       Date:  2022-05-24       Impact factor: 6.064

Review 3.  Endophytic and epiphytic microbes as "sources" of bioactive agents.

Authors:  David J Newman; Gordon M Cragg
Journal:  Front Chem       Date:  2015-05-22       Impact factor: 5.221

4.  C21 steroid-enriched fraction refined from Marsdenia tenacissima inhibits hepatocellular carcinoma through the coordination of Hippo-Yap and PTEN-PI3K/AKT signaling pathways.

Authors:  Yu Zhang; Kaiqiang Li; Youmin Ying; Bingyu Chen; Ke Hao; Boxu Chen; Yu Zheng; Jianxin Lyu; Xiangming Tong; Xiaopan Chen; Ying Wang; Zhajun Zhan; Wei Zhang; Zhen Wang
Journal:  Oncotarget       Date:  2017-11-30

Review 5.  Natural Nitrogenous Sesquiterpenoids and Their Bioactivity: A Review.

Authors:  De-Li Chen; Bo-Wen Wang; Zhao-Cui Sun; Jun-Shan Yang; Xu-Dong Xu; Guo-Xu Ma
Journal:  Molecules       Date:  2020-05-27       Impact factor: 4.411

Review 6.  Patents on Endophytic Fungi Related to Secondary Metabolites and Biotransformation Applications.

Authors:  Daniel Torres-Mendoza; Humberto E Ortega; Luis Cubilla-Rios
Journal:  J Fungi (Basel)       Date:  2020-05-01
  6 in total

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