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Literature DB >> 25220652

Lung transplant immunosuppression - time for a new approach?

Chad A Witt¹, Varun Puri, Andrew E Gelman, Alexander Sasha Krupnick, Daniel Kreisel.

Abstract

Outcomes after lung transplantation remain worse compared to other solid organ transplants, which is in large part due to high rates of graft rejection. Despite emerging data that immune responses to lungs differ from other organs, immunosuppression for lung transplant recipients is still based on strategies established for recipients of other grafts. There exists an urgent need to develop immunosuppressive strategies for lung transplant recipients that take the unique immunological features of this organ into account.

Entities: Chemical Disease Gene Species

Keywords: adaptive immunity; chronic rejection; graft rejection; immunosuppression; innate immunity; lung transplantation

Mesh：

Year: 2014 PMID： 25220652 PMCID： PMC4412736 DOI： 10.1586/1744666X.2014.959499

Source DB: PubMed Journal: Expert Rev Clin Immunol ISSN： 1744-666X Impact factor: 4.473

30 in total

1. Everolimus versus azathioprine in maintenance lung transplant recipients: an international, randomized, double-blind clinical trial.

Authors: G I Snell; V G Valentine; P Vitulo; A R Glanville; D C McGiffin; J E Loyd; A Roman; R Aris; A Sole; A Hmissi; U Pirron
Journal: Am J Transplant Date: 2006-01 Impact factor: 8.086

2. A randomized, double-blind, placebo-controlled, multicenter study of rabbit ATG in the prophylaxis of acute rejection in lung transplantation.

Authors: G I Snell; G P Westall; B J Levvey; P Jaksch; S Keshavjee; C W Hoopes; V Ahya; A Mehta; E P Trulock
Journal: Am J Transplant Date: 2014-03-11 Impact factor: 8.086

3. A randomized trial of inhaled cyclosporine in lung-transplant recipients.

Authors: Aldo T Iacono; Bruce A Johnson; Wayne F Grgurich; J Georges Youssef; Timothy E Corcoran; Deidre A Seiler; James H Dauber; Gerald C Smaldone; Adriana Zeevi; Samuel A Yousem; John J Fung; Gilbert J Burckart; Kenneth R McCurry; Bartley P Griffith
Journal: N Engl J Med Date: 2006-01-12 Impact factor: 91.245

4. Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome.

Authors: Geert M Verleden; Bart M Vanaudenaerde; Lieven J Dupont; Dirk E Van Raemdonck
Journal: Am J Respir Crit Care Med Date: 2006-06-01 Impact factor: 21.405

5. Innate immunity influences long-term outcomes after human lung transplant.

Authors: Scott M Palmer; Lauranell H Burch; Anil J Trindade; R Duane Davis; Walter F Herczyk; Nancy L Reinsmoen; David A Schwartz
Journal: Am J Respir Crit Care Med Date: 2005-01-07 Impact factor: 21.405

6. Photopheresis for the prevention of rejection in cardiac transplantation. Photopheresis Transplantation Study Group.

Authors: M L Barr; B M Meiser; H J Eisen; R F Roberts; U Livi; R Dall'Amico; R Dorent; J G Rogers; B Radovancević; D O Taylor; V Jeevanandam; C C Marboe
Journal: N Engl J Med Date: 1998-12-10 Impact factor: 91.245

Review 7. Long-term immunosuppression and malignancy in thoracic transplantation: where is the balance?

Authors: Nandini Nair; Enrique Gongora; Mandeep R Mehra
Journal: J Heart Lung Transplant Date: 2014-03-12 Impact factor: 10.247

8. A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation.

Authors: Ramsey R Hachem; Roger D Yusen; Murali M Chakinala; Bryan F Meyers; John P Lynch; Aviva A Aloush; G Alexander Patterson; Elbert P Trulock
Journal: J Heart Lung Transplant Date: 2007-10 Impact factor: 10.247

9. IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants.

Authors: William J Burlingham; Robert B Love; Ewa Jankowska-Gan; Lynn D Haynes; Qingyong Xu; Joseph L Bobadilla; Keith C Meyer; Mary S Hayney; Ruedi K Braun; Daniel S Greenspan; Bagavathi Gopalakrishnan; Junchao Cai; David D Brand; Shigetoshi Yoshida; Oscar W Cummings; David S Wilkes
Journal: J Clin Invest Date: 2007-11 Impact factor: 14.808

10. Airway anastomotic dehiscence associated with use of sirolimus immediately after lung transplantation.

Authors: Melissa B King-Biggs; Jordan M Dunitz; Soon J Park; S Kay Savik; Marshall I Hertz
Journal: Transplantation Date: 2003-05-15 Impact factor: 4.939

6 in total

1. Bronchus-associated lymphoid tissue-resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection.

Authors: Wenjun Li; Jason M Gauthier; Ryuji Higashikubo; Hsi-Min Hsiao; Satona Tanaka; Linh Vuong; Jon H Ritter; Alice Y Tong; Brian W Wong; Ramsey R Hachem; Varun Puri; Ankit Bharat; Alexander S Krupnick; Chyi S Hsieh; William M Baldwin; Francine L Kelly; Scott M Palmer; Andrew E Gelman; Daniel Kreisel
Journal: J Clin Invest Date: 2018-12-18 Impact factor: 14.808

2. Eosinophils downregulate lung alloimmunity by decreasing TCR signal transduction.

Authors: Oscar Okwudiri Onyema; Yizhan Guo; Bayan Mahgoub; Qing Wang; Amir Manafi; Zhongcheng Mei; Anirban Banerjee; Dongge Li; Mark H Stoler; Melissa T Zaidi; Adam G Schrum; Daniel Kreisel; Andrew E Gelman; Elizabeth A Jacobsen; Alexander Sasha Krupnick
Journal: JCI Insight Date: 2019-06-06

3. Ischemia reperfusion injury facilitates lung allograft acceptance through IL-33-mediated activation of donor-derived IL-5 producing group 2 innate lymphoid cells.

Authors: Yizhan Guo; Zhongcheng Mei; Dongge Li; Anirban Banerjee; May A Khalil; Allen Burke; Jon Ritter; Christine Lau; Daniel Kreisel; Andrew E Gelman; Elizabeth Jacobsen; Irina G Luzina; Sergei P Atamas; Alexander Sasha Krupnick
Journal: Am J Transplant Date: 2022-05-17 Impact factor: 9.369