Yudan He1, Siyi Chen1, Zixun Liu1, Chu Cheng1, Hui Li1, Minqi Wang2. 1. Feed Science Institute, College of Animal Science, Zhejiang University, No. 866, Yuhangtang Road, Hangzhou 310058, Zhejiang, China. 2. Feed Science Institute, College of Animal Science, Zhejiang University, No. 866, Yuhangtang Road, Hangzhou 310058, Zhejiang, China. Electronic address: wangmq@zju.edu.cn.
Abstract
AIMS: We synthesized selenium nanoparticles (SeNPs) and examined their toxicity in male rats at supranutritional and nonlethal doses. MAIN METHODS: The SeNPs were administered daily by gavage at doses of 0.0, 0.2, 0.4, 0.8, 2.0, 4.0, or 8.0 mg Se/kg-body weight (bw) in 2 mL of 0.9% saline for 14 consecutive days. Body weight, viscera index and blood biochemical parameters were measured. Histopathological examination was performed on selected tissues, and liver tissue was examined for apoptotic cells. KEY FINDINGS: Body weight decreased considerably in the groups given doses of 2.0, 4.0, and 8.0 mg Se/kg-bw, but increased in the groups given doses of 0.2 and 0.4 mg Se/kg-bw. The viscera index and some biochemical parameters in the 8.0 mg Se/kg-bw group differed from the control group. Lesions in the liver, kidneys, lungs, and thymus, and apoptotic liver cells were observed in the 4.0 and 8.0 mg Se/kg-bw groups. SIGNIFICANCE: From this study, we conclude that supranutritional levels of SeNPs had no obvious toxic effects in rats, and could be used as potential candidates for cancer chemoprevention, although doses greater than 2.0 mg Se/kg-bw induced chronic toxicity.
AIMS: We synthesized selenium nanoparticles (SeNPs) and examined their toxicity in male rats at supranutritional and nonlethal doses. MAIN METHODS: The SeNPs were administered daily by gavage at doses of 0.0, 0.2, 0.4, 0.8, 2.0, 4.0, or 8.0 mg Se/kg-body weight (bw) in 2 mL of 0.9% saline for 14 consecutive days. Body weight, viscera index and blood biochemical parameters were measured. Histopathological examination was performed on selected tissues, and liver tissue was examined for apoptotic cells. KEY FINDINGS: Body weight decreased considerably in the groups given doses of 2.0, 4.0, and 8.0 mg Se/kg-bw, but increased in the groups given doses of 0.2 and 0.4 mg Se/kg-bw. The viscera index and some biochemical parameters in the 8.0 mg Se/kg-bw group differed from the control group. Lesions in the liver, kidneys, lungs, and thymus, and apoptotic liver cells were observed in the 4.0 and 8.0 mg Se/kg-bw groups. SIGNIFICANCE: From this study, we conclude that supranutritional levels of SeNPs had no obvious toxic effects in rats, and could be used as potential candidates for cancer chemoprevention, although doses greater than 2.0 mg Se/kg-bw induced chronic toxicity.
Authors: Alline Gomes Pereira; Luanai Graziele Luquini Gerolis; Letícia Satler Gonçalves; Luciana Mara Costa Moreira; Pedro Lana Gastelois; Maria Jose Neves Journal: World J Microbiol Biotechnol Date: 2022-01-06 Impact factor: 3.312