Literature DB >> 25219617

DNA methylation state of BDNF gene is not altered in prefrontal cortex and striatum of schizophrenia subjects.

Simona Keller1, Francesco Errico2, Federica Zarrilli3, Ermanno Florio4, Daniela Punzo2, Sonia Mansueto5, Tiziana Angrisano6, Raffaela Pero6, Francesca Lembo7, Giuseppe Castaldo8, Alessandro Usiello2, Lorenzo Chiariotti9.   

Abstract

In this study we assessed the BDNF promoter IV methylation state of a large genomic region surrounding promoter IV and evaluated BDNF transcript IV expression from prefrontal cortex and striatum of 15 schizophrenic and 15 control subjects. In prefrontal cortex, a single CpG site at -93, appeared to be undermethylated in patients׳group. BDNF mRNA levels in frontal cortex and striatum were variable among individuals but did not associate with disease.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  BDNF; DNA methylation; Schizophrenia

Mesh：

Substances：

Year:  2014        PMID： 25219617     DOI： 10.1016/j.psychres.2014.08.022

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  7 in total

Review 1.  Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia.

Authors:  Ariel Cariaga-Martinez; Raúl Alelú-Paz
Journal:  Int J Mol Sci       Date:  2017-04-07       Impact factor: 5.923

2.  Tracking the evolution of epialleles during neural differentiation and brain development: D-Aspartate oxidase as a model gene.

Authors:  Ermanno Florio; Simona Keller; Lorena Coretti; Ornella Affinito; Giovanni Scala; Francesco Errico; Annalisa Fico; Francesca Boscia; Maria Josè Sisalli; Mafalda Giovanna Reccia; Gennaro Miele; Antonella Monticelli; Antonella Scorziello; Francesca Lembo; Luca Colucci-D'Amato; Gabriella Minchiotti; Vittorio Enrico Avvedimento; Alessandro Usiello; Sergio Cocozza; Lorenzo Chiariotti
Journal:  Epigenetics       Date:  2016-11-18       Impact factor: 4.528

3.  DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia.

Authors:  Simona Keller; Daniela Punzo; Mariella Cuomo; Ornella Affinito; Lorena Coretti; Silvia Sacchi; Ermanno Florio; Francesca Lembo; Massimo Carella; Massimiliano Copetti; Sergio Cocozza; Darrick T Balu; Francesco Errico; Alessandro Usiello; Lorenzo Chiariotti
Journal:  Sci Rep       Date:  2018-07-05       Impact factor: 4.379

Review 4.  Brain-derived neurotrophic factor and mental disorders.

Authors:  Chin-Chuen Lin; Tiao-Lai Huang
Journal:  Biomed J       Date:  2020-05-05       Impact factor: 4.910

5.  Urinary Biomarkers: Diagnostic Tools for Monitoring Athletes' Health Status.

Authors:  Raffaela Pero; Mariarita Brancaccio; Cristina Mennitti; Luca Gentile; Sergio Arpino; Renato De Falco; Eleonora Leggiero; Annaluisa Ranieri; Chiara Pagliuca; Roberta Colicchio; Paola Salvatore; Giovanni D'Alicandro; Giulia Frisso; Barbara Lombardo; Cristina Mazzaccara; Raffaella Faraonio; Olga Scudiero
Journal:  Int J Environ Res Public Health       Date:  2020-08-20       Impact factor: 3.390

6.  Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings.

Authors:  Lukasz Smigielski; Vinita Jagannath; Wulf Rössler; Susanne Walitza; Edna Grünblatt
Journal:  Mol Psychiatry       Date:  2020-01-06       Impact factor: 15.992

7.  Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of D-serine within the mouse cerebellum.

Authors:  Mariella Cuomo; Simona Keller; Daniela Punzo; Tommaso Nuzzo; Ornella Affinito; Lorena Coretti; Massimo Carella; Valeria de Rosa; Ermanno Florio; Francesca Boscia; Vittorio Enrico Avvedimento; Sergio Cocozza; Francesco Errico; Alessandro Usiello; Lorenzo Chiariotti
Journal:  Clin Epigenetics       Date:  2019-10-28       Impact factor: 6.551
  7 in total

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