Weisi Liu1, Yidong Liu1, Haiou Liu1, Weijuan Zhang2, Huimin An3, Jiejie Xu4. 1. Key Laboratory of Glycoconjugate Research, MOH, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, China. 2. Department of Immunology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, China. 3. Department of Urology, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China. 4. Key Laboratory of Glycoconjugate Research, MOH, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, China. Electronic address: jjxufdu@fudan.edu.cn.
Abstract
BACKGROUND: Snail (known as SNAI1), a zinc-finger transcription factor, is best known for the induction of epithelial-to-mesenchymal transition, which has emerged as a recognized mechanism underlying epithelial cancer progression. Herein, the aim is to determine the effect of Snail expression on recurrence and survival of patients with localized clear cell renal cell carcinoma (ccRCC) following surgery. METHODS: We retrospectively enrolled 255 patients (188 in group A and 67 in group B) with localized ccRCC undergoing nephrectomy at a single center. Prognostic value and clinical outcomes were evaluated. RESULTS: In both groups, cytoplasmic Snail intensity correlates positively with Fuhrman grade. High nuclear but not cytoplasmic Snail intensity indicates early recurrence and poor survival of patients with localized ccRCC. Moreover, high nuclear Snail intensity predicts unfavorable survival of patients with T2-4 stage cancer and early recurrence of all stage patients. Nuclear Snail intensity was identified as an independent adverse prognostic factor for recurrence and survival. The predictive accuracy of University of Los Angeles Integrated Staging System and the Mayo Clinic Stage, Size, Grade, and Necrosis prognostic models was improved when nuclear Snail expression was added. CONCLUSION: Nuclear Snail expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with localized ccRCC after nephrectomy.
BACKGROUND:Snail (known as SNAI1), a zinc-finger transcription factor, is best known for the induction of epithelial-to-mesenchymal transition, which has emerged as a recognized mechanism underlying epithelial cancer progression. Herein, the aim is to determine the effect of Snail expression on recurrence and survival of patients with localized clear cell renal cell carcinoma (ccRCC) following surgery. METHODS: We retrospectively enrolled 255 patients (188 in group A and 67 in group B) with localized ccRCC undergoing nephrectomy at a single center. Prognostic value and clinical outcomes were evaluated. RESULTS: In both groups, cytoplasmic Snail intensity correlates positively with Fuhrman grade. High nuclear but not cytoplasmic Snail intensity indicates early recurrence and poor survival of patients with localized ccRCC. Moreover, high nuclear Snail intensity predicts unfavorable survival of patients with T2-4 stage cancer and early recurrence of all stage patients. Nuclear Snail intensity was identified as an independent adverse prognostic factor for recurrence and survival. The predictive accuracy of University of Los Angeles Integrated Staging System and the Mayo Clinic Stage, Size, Grade, and Necrosis prognostic models was improved when nuclear Snail expression was added. CONCLUSION: Nuclear Snail expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with localized ccRCC after nephrectomy.
Authors: Laura Zaldumbide; Asier Erramuzpe; Rosa Guarch; Rafael Pulido; Jesús M Cortés; José I López Journal: BMC Cancer Date: 2016-03-08 Impact factor: 4.430
Authors: Hana Mlcochova; Tana Machackova; Anja Rabien; Lenka Radova; Pavel Fabian; Robert Iliev; Katerina Slaba; Alexandr Poprach; Ergin Kilic; Michal Stanik; Martina Redova-Lojova; Marek Svoboda; Jan Dolezel; Rostislav Vyzula; Klaus Jung; Ondrej Slaby Journal: Sci Rep Date: 2016-08-23 Impact factor: 4.379