Stig Lønberg Nielsen1, Annmarie Touborg Lassen2, Kim Oren Gradel3, Thøger Gorm Jensen4, Hans Jørn Kolmos4, Jesper Hallas5, Court Pedersen6. 1. Department of Infectious Diseases, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark. Electronic address: stig.nielsen@rsyd.dk. 2. Department of Emergency Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark. 3. Center for Clinical Epidemiology, South, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark; Research Unit of Clinical Epidemiology, Institute of Clinical Research, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. 4. Department of Clinical Microbiology, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark. 5. Research Unit of Clinical Pharmacology, University of Southern Denmark, Sdr. Boulevard 29, 5000 Odense C, Denmark. 6. Department of Infectious Diseases, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark.
Abstract
OBJECTIVES: Little is known about long-term outcomes following bacteremia. We investigated long-term mortality and causes of death among bacteremia patients compared with population controls. METHODS: Population-based cohort study of bacteremia patients and population controls matched on sex, year of birth, residency and calendar time, in Denmark during 2000-2008. We calculated absolute mortality and adjusted mortality rate ratios (MRRs) in predefined follow-up periods. RESULTS: The absolute mortality for bacteremia patients (n = 7783) and population controls (n = 38,906) was 22.0% vs. 0.2% (30 days), 41.4% vs. 2.6% (1 year) and 75.8% vs. 36.6% (10 years). For bacteremia patients, the MRR was 115.3 (95% CI, 88.2-150.9) 0-30 days after bacteremia and 2.1 (95% CI, 1.8-2.3) from 5 years to end of follow-up. The most common causes of death were cancer and cardiovascular diseases. Within one year of bacteremia, the relative risk of death was highest for genitourinary diseases and infectious diseases. Among one-year survivors of bacteremia, the relative risk of death was increased for all major causes of death. CONCLUSIONS: Bacteremia is associated with a poor prognosis and considerable excess long-term mortality compared with the general population. The most common causes of death after bacteremia are cancer and cardiovascular diseases. SUMMARY: This population-based cohort study reports an excess long-term mortality among 7783 bacteremia patients compared with matched population controls during 12 years of follow-up. We identified patients in particular risk of death and reported novel information on causes of death.
OBJECTIVES: Little is known about long-term outcomes following bacteremia. We investigated long-term mortality and causes of death among bacteremiapatients compared with population controls. METHODS: Population-based cohort study of bacteremiapatients and population controls matched on sex, year of birth, residency and calendar time, in Denmark during 2000-2008. We calculated absolute mortality and adjusted mortality rate ratios (MRRs) in predefined follow-up periods. RESULTS: The absolute mortality for bacteremiapatients (n = 7783) and population controls (n = 38,906) was 22.0% vs. 0.2% (30 days), 41.4% vs. 2.6% (1 year) and 75.8% vs. 36.6% (10 years). For bacteremiapatients, the MRR was 115.3 (95% CI, 88.2-150.9) 0-30 days after bacteremia and 2.1 (95% CI, 1.8-2.3) from 5 years to end of follow-up. The most common causes of death were cancer and cardiovascular diseases. Within one year of bacteremia, the relative risk of death was highest for genitourinary diseases and infectious diseases. Among one-year survivors of bacteremia, the relative risk of death was increased for all major causes of death. CONCLUSIONS:Bacteremia is associated with a poor prognosis and considerable excess long-term mortality compared with the general population. The most common causes of death after bacteremia are cancer and cardiovascular diseases. SUMMARY: This population-based cohort study reports an excess long-term mortality among 7783 bacteremiapatients compared with matched population controls during 12 years of follow-up. We identified patients in particular risk of death and reported novel information on causes of death.
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