Katja Airaksinen1, Jyrki P Mäkelä2, Jussi Nurminen2, Jarkko Luoma2, Samu Taulu3, Antti Ahonen3, Eero Pekkonen4. 1. BioMag Laboratory, HUS Medical Imaging Center, Helsinki University Central Hospital, Finland; Department of Neurology, Helsinki University Central Hospital, Finland. Electronic address: katja.airaksinen@helsinki.fi. 2. BioMag Laboratory, HUS Medical Imaging Center, Helsinki University Central Hospital, Finland. 3. Elekta Oy, Helsinki, Finland. 4. Department of Neurology, Helsinki University Central Hospital, Finland.
Abstract
OBJECTIVE: Cortico-muscular coherence (CMC) is thought to reflect the interplay between cortex and muscle in motor coordination. In Parkinson's disease (PD) patients, levodopa has been shown to enhance CMC. This study examined whether subthalamic nucleus (STN) deep brain stimulation (DBS) affects the CMC in advanced PD. METHODS: Magnetoencephalography (MEG) and electromyography (EMG) measurements were done simultaneously both with DBS on and off to determine the CMC during wrist extension. The spatiotemporal signal space separation (tSSS) was used for artifact suppression. RESULTS: CMC peaks between 13 and 25 Hz were found in 15 out of 19 patients. The effect of DBS on CMC was variable. Moreover, the correlation between CMC and motor performance was inconsistent; stronger CMC did not necessarily indicate better function albeit tremor and rigidity may diminish the CMC. Patients having CMC between 13 and 25 Hz had the best motor scores at the group level. CONCLUSIONS: DBS modifies the CMC in advanced PD with large interindividual variability. SIGNIFICANCE: DBS does not systematically modify CMC amplitude in advanced PD. The results suggest that some components of the CMC may be related to the therapeutic effects of DBS.
OBJECTIVE: Cortico-muscular coherence (CMC) is thought to reflect the interplay between cortex and muscle in motor coordination. In Parkinson's disease (PD) patients, levodopa has been shown to enhance CMC. This study examined whether subthalamic nucleus (STN) deep brain stimulation (DBS) affects the CMC in advanced PD. METHODS: Magnetoencephalography (MEG) and electromyography (EMG) measurements were done simultaneously both with DBS on and off to determine the CMC during wrist extension. The spatiotemporal signal space separation (tSSS) was used for artifact suppression. RESULTS:CMC peaks between 13 and 25 Hz were found in 15 out of 19 patients. The effect of DBS on CMC was variable. Moreover, the correlation between CMC and motor performance was inconsistent; stronger CMC did not necessarily indicate better function albeit tremor and rigidity may diminish the CMC. Patients having CMC between 13 and 25 Hz had the best motor scores at the group level. CONCLUSIONS: DBS modifies the CMC in advanced PD with large interindividual variability. SIGNIFICANCE: DBS does not systematically modify CMC amplitude in advanced PD. The results suggest that some components of the CMC may be related to the therapeutic effects of DBS.
Authors: Minna Pitkänen; Shogo Yazawa; Katja Airaksinen; Pantelis Lioumis; Jussi Nurminen; Eero Pekkonen; Jyrki P Mäkelä Journal: Brain Topogr Date: 2019-05-15 Impact factor: 3.020
Authors: Gyeong Seon Choi; Ji Young Yun; Sungeun Hwang; Song E Kim; Jeong-Yeon Kim; Chang-Hwan Im; Hyang Woon Lee Journal: J Clin Med Date: 2021-11-27 Impact factor: 4.241
Authors: Richard Wennberg; J Martin Del Campo; Nat Shampur; Nathan C Rowland; Taufik Valiante; Andres M Lozano; Luis Garcia Dominguez Journal: Epilepsia Open Date: 2016-12-09