OBJECTIVES: This article reports the cross-studies analysis of projects from the P30 Center of Excellence for Biobehavioral Approaches to Symptom Management. Although the projects investigated diverse populations, a consistent theoretical and empirical approach guided each project. METHODS: Common data elements included the following measures of psychobehavioral variables: the PROMIS Short-Form Fatigue Scale, the Center of Epidemiologic Studies Depression Scale, and the Perceived Stress Scale. Plasma cytokines were measured as the shared biological data element. RESULTS: Data were analyzed from 295 participants with fibromyalgia (n = 72), second trimester pregnancy (n = 73), sickle cell anemia (n = 60), and cardiometabolic risk (n = 91). The mean age of participants was 35.4 years, and the most participants were female. Levels of symptoms were generally elevated across samples; the level of fatigue ranged from 18.9 to 24.7, depressive symptoms from 12.5 to 23.4, and perceived stress from 16.5 to 21.8. Intercorrelations among symptom measures and perceived stress were strong across the samples. However, correlations among psychobehavioral variables and cytokines were variable, indicating a separate relationship for the measures with cytokines. CONCLUSIONS: Future work in symptom science could benefit from common data elements, including biomarkers, across populations to better develop the taxonomy of symptom profiles across conditions.
OBJECTIVES: This article reports the cross-studies analysis of projects from the P30 Center of Excellence for Biobehavioral Approaches to Symptom Management. Although the projects investigated diverse populations, a consistent theoretical and empirical approach guided each project. METHODS: Common data elements included the following measures of psychobehavioral variables: the PROMIS Short-Form Fatigue Scale, the Center of Epidemiologic Studies Depression Scale, and the Perceived Stress Scale. Plasma cytokines were measured as the shared biological data element. RESULTS: Data were analyzed from 295 participants with fibromyalgia (n = 72), second trimester pregnancy (n = 73), sickle cell anemia (n = 60), and cardiometabolic risk (n = 91). The mean age of participants was 35.4 years, and the most participants were female. Levels of symptoms were generally elevated across samples; the level of fatigue ranged from 18.9 to 24.7, depressive symptoms from 12.5 to 23.4, and perceived stress from 16.5 to 21.8. Intercorrelations among symptom measures and perceived stress were strong across the samples. However, correlations among psychobehavioral variables and cytokines were variable, indicating a separate relationship for the measures with cytokines. CONCLUSIONS: Future work in symptom science could benefit from common data elements, including biomarkers, across populations to better develop the taxonomy of symptom profiles across conditions.
Authors: Jin-Shei Lai; David Cella; Seung Choi; Doerte U Junghaenel; Christopher Christodoulou; Richard Gershon; Arthur Stone Journal: Arch Phys Med Rehabil Date: 2011-10 Impact factor: 3.966
Authors: Sean X Leng; Janet E McElhaney; Jeremy D Walston; Dongxu Xie; Neal S Fedarko; George A Kuchel Journal: J Gerontol A Biol Sci Med Sci Date: 2008-08 Impact factor: 6.053
Authors: Ali Ezzati; Julie Jiang; Mindy J Katz; Martin J Sliwinski; Molly E Zimmerman; Richard B Lipton Journal: Int J Geriatr Psychiatry Date: 2013-12-03 Impact factor: 3.485
Authors: Kathleen T Hickey; Suzanne Bakken; Mary W Byrne; Donald Chip E Bailey; George Demiris; Sharron L Docherty; Susan G Dorsey; Barbara J Guthrie; Margaret M Heitkemper; Cynthia S Jacelon; Teresa J Kelechi; Shirley M Moore; Nancy S Redeker; Cynthia L Renn; Barbara Resnick; Angela Starkweather; Hilaire Thompson; Teresa M Ward; Donna Jo McCloskey; Joan K Austin; Patricia A Grady Journal: Nurs Outlook Date: 2019-01-18 Impact factor: 3.250
Authors: Ho Ting Wong; Vico Chung Lim Chiang; Kup Sze Choi; Alice Yuen Loke Journal: Int J Environ Res Public Health Date: 2016-10-17 Impact factor: 3.390