Siddhivinayak Hirve1, Anand Krishnan2, Fatimah S Dawood3, Pallavi Lele1, Siddhartha Saha3, Sanjay Rai2, Vivek Gupta4, Kathryn E Lafond3, Sanjay Juvekar1, Varsha Potdar5, Shobha Broor6, Renu B Lal3, Mandeep Chadha7. 1. Vadu Rural Health Program, King Edward Memorial Hospital Research Center, Pune, India. 2. Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India. 3. Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, USA. 4. National Institute of Mental Health and Allied Sciences, Bangalore, India. 5. National Institute of Virology, Indian Council of Medical Research, 20-A, Dr Ambedkar Road, Pune 411001, India. 6. INCLEN Trust International, New Delhi, India. 7. National Institute of Virology, Indian Council of Medical Research, 20-A, Dr Ambedkar Road, Pune 411001, India. Electronic address: mscniv@gmail.com.
Abstract
BACKGROUND: The global burden of influenza is increasingly recognized, but data from India remain sparse. We conducted a multi-site population-based surveillance study to estimate and compare rates of influenza-associated hospitalization at two rural Indian health and demographic surveillance system (HDSS) sites at Ballabgarh and Vadu during 2010-2012. METHODS: Prospective facility-based surveillance for all hospitalizations (excluding those for trauma, elective surgery and obstetric, ophthalmic or psychiatric reasons) was conducted at 72 health facilities. After collection of clinical details, patients had nasopharyngeal swabs taken and tested by reverse transcription polymerase chain reaction for influenza viruses. Annual healthcare utilization surveys (HUS) were conducted in HDSS households to identify proportion of hospitalizations occurring at non-study facilities to adjust for hospitalizations missed through facility-based surveillance. RESULTS: HUS showed that 69% and 67% of hospitalizations occurred at study facilities at Ballabgarh and Vadu, respectively. Overall, 6004 patients hospitalized with acute medical illness at participating facilities were enrolled (1717 from Ballabgarh; 4287 from Vadu). The proportion of patients with influenza was higher at Vadu than Ballabgarh annually (2010: 21% vs. 5%, p < 0.05; 2011: 18% vs. 5%, p < 0.05; 2012: 23% vs. 5%, p < 0.05). Annual adjusted influenza-associated hospitalization rates were 5-11 fold higher in Vadu (20.3-51.6 per 10,000) vs Ballabgarh (4.4-6.3 per 10,000). At both sites, influenza A/H1N1pdm09 and B predominated during 2010, A/H3N2 and B during 2011, and A/H1N1pdm09 and B during 2012. CONCLUSION: The markedly different influenza hospitalization rates by season and across communities in India highlight the need for sustained multi-site surveillance system for estimating national influenza disease burden. That would be the first step for initiating discussions around Influenza prevention and control strategies in the country.
BACKGROUND: The global burden of influenza is increasingly recognized, but data from India remain sparse. We conducted a multi-site population-based surveillance study to estimate and compare rates of influenza-associated hospitalization at two rural Indian health and demographic surveillance system (HDSS) sites at Ballabgarh and Vadu during 2010-2012. METHODS: Prospective facility-based surveillance for all hospitalizations (excluding those for trauma, elective surgery and obstetric, ophthalmic or psychiatric reasons) was conducted at 72 health facilities. After collection of clinical details, patients had nasopharyngeal swabs taken and tested by reverse transcription polymerase chain reaction for influenza viruses. Annual healthcare utilization surveys (HUS) were conducted in HDSS households to identify proportion of hospitalizations occurring at non-study facilities to adjust for hospitalizations missed through facility-based surveillance. RESULTS:HUS showed that 69% and 67% of hospitalizations occurred at study facilities at Ballabgarh and Vadu, respectively. Overall, 6004 patients hospitalized with acute medical illness at participating facilities were enrolled (1717 from Ballabgarh; 4287 from Vadu). The proportion of patients with influenza was higher at Vadu than Ballabgarh annually (2010: 21% vs. 5%, p < 0.05; 2011: 18% vs. 5%, p < 0.05; 2012: 23% vs. 5%, p < 0.05). Annual adjusted influenza-associated hospitalization rates were 5-11 fold higher in Vadu (20.3-51.6 per 10,000) vs Ballabgarh (4.4-6.3 per 10,000). At both sites, influenza A/H1N1pdm09 and B predominated during 2010, A/H3N2 and B during 2011, and A/H1N1pdm09 and B during 2012. CONCLUSION: The markedly different influenza hospitalization rates by season and across communities in India highlight the need for sustained multi-site surveillance system for estimating national influenza disease burden. That would be the first step for initiating discussions around Influenza prevention and control strategies in the country.
Authors: Mark G Thompson; Min Z Levine; Silvia Bino; Danielle R Hunt; Tareq M Al-Sanouri; Eric A F Simões; Rachael M Porter; Holly M Biggs; Lionel Gresh; Artan Simaku; Illham Abu Khader; Veronica L Tallo; Jennifer K Meece; Meredith McMorrow; Edelwisa S Mercado; Sneha Joshi; Nicholas P DeGroote; Iris Hatibi; Felix Sanchez; Marilla G Lucero; Samir Faouri; Stacie N Jefferson; Numila Maliqari; Angel Balmaseda; Diozele Sanvictores; Crystal Holiday; Cristina Sciuto; Zachary Owens; Eduardo Azziz-Baumgartner; Aubree Gordon Journal: Lancet Child Adolesc Health Date: 2019-09-03
Authors: Joan Puig-Barberà; Anita Tormos; Svetlana Trushakova; Anna Sominina; Maria Pisareva; Meral A Ciblak; Selim Badur; Hongjie Yu; Benjamin J Cowling; Elena Burtseva Journal: Influenza Other Respir Viruses Date: 2015-11 Impact factor: 4.380
Authors: Mark G Thompson; Danielle R Hunt; Ali K Arbaji; Artan Simaku; Veronica L Tallo; Holly M Biggs; Carolyn Kulb; Aubree Gordon; Ilham Abu Khader; Silvia Bino; Marilla G Lucero; Eduardo Azziz-Baumgartner; Pat Shifflett; Felix Sanchez; Basima I Marar; Ilirjana Bakalli; Eric A F Simões; Min Z Levine; Jennifer K Meece; Angel Balmaseda; Tareq M Al-Sanouri; Majlinda Dhimolea; Joanne N de Jesus; Natalie J Thornburg; Susan I Gerber; Lionel Gresh Journal: BMC Infect Dis Date: 2017-03-22 Impact factor: 3.090
Authors: Mazhar Hussain; Henry D Galvin; Tatt Y Haw; Ashley N Nutsford; Matloob Husain Journal: Infect Drug Resist Date: 2017-04-20 Impact factor: 4.003
Authors: M Teresa Aguado; Jane Barratt; John R Beard; Bonnie B Blomberg; Wilbur H Chen; Julian Hickling; Terri B Hyde; Mark Jit; Rebecca Jones; Gregory A Poland; Martin Friede; Justin R Ortiz Journal: Vaccine Date: 2018-01-12 Impact factor: 3.641