Teresa A VanWort1, Joseph A Lee2, Hrishikesh Karvir3, Michael C Whitehouse2, Piraye Yurttas Beim3, Alan B Copperman4. 1. Reproductive Medicine Associates of New York, New York, New York; Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, New York, New York. Electronic address: tvanwort@rmany.com. 2. Reproductive Medicine Associates of New York, New York, New York. 3. Celmatix Inc., New York, New York. 4. Reproductive Medicine Associates of New York, New York, New York; Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, New York, New York.
Abstract
OBJECTIVE: To evaluate the association between female cystic fibrosis (CF) carrier status and in vitro fertilization (IVF) response and outcomes. The presence of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in male carriers has been associated with infertility, yet possible adverse effects on the ovarian function and reproductive outcomes of female carriers have not been studied to date. DESIGN: Retrospective cohort study. SETTING: Private academic, clinical reproductive center. PATIENT(S): Females<40 years of age who were screened for CFTR mutations and received IVF treatment between July 2002 and March 2013. INTERVENTION(S): Patients initiated controlled ovarian hyperstimulation with frequent monitoring, vaginal oocyte retrieval, fertilization, embryo transfer, and a pregnancy test. Various measures of IVF stimulation response and cycle outcome were evaluated for both carriers and noncarriers. MAIN OUTCOME MEASURE(S): Analysis was performed by logistic regression and Poisson regression. RESULT(S): IVF cycles (n=199) from CFTR mutation carrier patients (n=112) were analyzed. No significant differences in outcome were noted when carriers of different mutation loci were compared in aggregate with the noncarrier group (n=6,420 cycles from 3,555 patients). Significant differences were noted for some metrics when the carriers were grouped by mutation loci. CONCLUSION(S): Overall, no significant differences in stimulation response and cycle outcome were noted between female CFTR mutation carriers and noncarriers. Further research is needed to investigate whether the differences noted between specific CFTR mutation loci are clinically relevant and whether CFTR mutations may impact reproductive outcomes outside the context of assisted reproductive technologies.
OBJECTIVE: To evaluate the association between female cystic fibrosis (CF) carrier status and in vitro fertilization (IVF) response and outcomes. The presence of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in male carriers has been associated with infertility, yet possible adverse effects on the ovarian function and reproductive outcomes of female carriers have not been studied to date. DESIGN: Retrospective cohort study. SETTING: Private academic, clinical reproductive center. PATIENT(S): Females<40 years of age who were screened for CFTR mutations and received IVF treatment between July 2002 and March 2013. INTERVENTION(S): Patients initiated controlled ovarian hyperstimulation with frequent monitoring, vaginal oocyte retrieval, fertilization, embryo transfer, and a pregnancy test. Various measures of IVF stimulation response and cycle outcome were evaluated for both carriers and noncarriers. MAIN OUTCOME MEASURE(S): Analysis was performed by logistic regression and Poisson regression. RESULT(S): IVF cycles (n=199) from CFTR mutation carrier patients (n=112) were analyzed. No significant differences in outcome were noted when carriers of different mutation loci were compared in aggregate with the noncarrier group (n=6,420 cycles from 3,555 patients). Significant differences were noted for some metrics when the carriers were grouped by mutation loci. CONCLUSION(S): Overall, no significant differences in stimulation response and cycle outcome were noted between female CFTR mutation carriers and noncarriers. Further research is needed to investigate whether the differences noted between specific CFTR mutation loci are clinically relevant and whether CFTR mutations may impact reproductive outcomes outside the context of assisted reproductive technologies.
Authors: Kate E O'Connor; Dana L Goodwin; Andrew NeSmith; Bryan Garcia; Christina Mingora; Sigrid L Ladores; Steve M Rowe; Stefanie Krick; George M Solomon Journal: J Cyst Fibros Date: 2021-01-19 Impact factor: 5.527