Literature DB >> 25217085

[Successful therapy of metastatic basal cell carcinoma with vismodegib].

M Zutt1, F Mazur, M Bergmann, A J Lemke, K M Kaune.   

Abstract

A 71-year-old man presented with giant basal cell carcinoma on the abdomen which had metastasized. He was treated with oral vismodegib. Both the primary ulcerated tumor on the abdomen and the metastases responded. Vismodegib was well tolerated without significant side effects. The tumor recurred promptly after vismodegib was discontinued, and then was resistant to therapy when vismodegib was re-administered.

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Year:  2014        PMID： 25217085     DOI： 10.1007/s00105-014-3503-y

Source DB:  PubMed          Journal:  Hautarzt        ISSN： 0017-8470            Impact factor:   0.751


  6 in total

Review 1.  Advances in the treatment of Basal cell carcinoma: Hedgehog inhibitors.

Authors:  Ragini Kudchadkar; Karl Lewis; Rene Gonzalez
Journal:  Semin Oncol       Date:  2012-04       Impact factor: 4.929

2.  The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.

Authors:  M R Gailani; M Ståhle-Bäckdahl; D J Leffell; M Glynn; P G Zaphiropoulos; C Pressman; A B Undén; M Dean; D E Brash; A E Bale; R Toftgård
Journal:  Nat Genet       Date:  1996-09       Impact factor: 38.330

3.  Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling.

Authors:  Nikhil Wagle; Caroline Emery; Michael F Berger; Matthew J Davis; Allison Sawyer; Panisa Pochanard; Sarah M Kehoe; Cory M Johannessen; Laura E Macconaill; William C Hahn; Matthew Meyerson; Levi A Garraway
Journal:  J Clin Oncol       Date:  2011-03-07       Impact factor: 44.544

4.  Efficacy and safety of vismodegib in advanced basal-cell carcinoma.

Authors:  Aleksandar Sekulic; Michael R Migden; Anthony E Oro; Luc Dirix; Karl D Lewis; John D Hainsworth; James A Solomon; Simon Yoo; Sarah T Arron; Philip A Friedlander; Ellen Marmur; Charles M Rudin; Anne Lynn S Chang; Jennifer A Low; Howard M Mackey; Robert L Yauch; Richard A Graham; Josina C Reddy; Axel Hauschild
Journal:  N Engl J Med       Date:  2012-06-07       Impact factor: 91.245

5.  Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome.

Authors:  Jean Y Tang; Julian M Mackay-Wiggan; Michelle Aszterbaum; Robert L Yauch; Joselyn Lindgren; Kris Chang; Carol Coppola; Anita M Chanana; Jackleen Marji; David R Bickers; Ervin H Epstein
Journal:  N Engl J Med       Date:  2012-06-07       Impact factor: 91.245

6.  Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.

Authors:  Daniel D Von Hoff; Patricia M LoRusso; Charles M Rudin; Josina C Reddy; Robert L Yauch; Raoul Tibes; Glen J Weiss; Mitesh J Borad; Christine L Hann; Julie R Brahmer; Howard M Mackey; Bertram L Lum; Walter C Darbonne; James C Marsters; Frederic J de Sauvage; Jennifer A Low
Journal:  N Engl J Med       Date:  2009-09-02       Impact factor: 91.245
  6 in total

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