Literature DB >> 25217053

Differential regulation of germline apoptosis in response to meiotic checkpoint activation.

Alice L Ye1, J Matthew Ragle1, Barbara Conradt2, Needhi Bhalla3.   

Abstract

In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.
Copyright © 2014 by the Genetics Society of America.

Entities:  

Keywords:  DNA damage; apoptosis; checkpoint; recombination; synapsis

Mesh：

Substances：

Year:  2014        PMID： 25217053      PMCID： PMC4224185          DOI： 10.1534/genetics.114.170241

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  26 in total

1.  Trithorax, Hox, and TALE-class homeodomain proteins ensure cell survival through repression of the BH3-only gene egl-1.

Authors:  Malia B Potts; David P Wang; Scott Cameron
Journal:  Dev Biol       Date:  2009-02-28       Impact factor: 3.582

Review 2.  Prelude to a division.

Authors:  Needhi Bhalla; Abby F Dernburg
Journal:  Annu Rev Cell Dev Biol       Date:  2008       Impact factor: 13.827

3.  A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans.

Authors:  Needhi Bhalla; Abby F Dernburg
Journal:  Science       Date:  2005-12-09       Impact factor: 47.728

4.  Multimodal RNA-seq using single-strand, double-strand, and CircLigase-based capture yields a refined and extended description of the C. elegans transcriptome.

Authors:  Ayelet T Lamm; Michael R Stadler; Huibin Zhang; Jonathan I Gent; Andrew Z Fire
Journal:  Genome Res       Date:  2010-12-22       Impact factor: 9.043

5.  Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1.

Authors:  Huarui Liu; Tamara J Strauss; Malia B Potts; Scott Cameron
Journal:  Development       Date:  2006-01-18       Impact factor: 6.868

6.  C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage.

Authors:  B Schumacher; C Schertel; N Wittenburg; S Tuck; S Mitani; A Gartner; B Conradt; S Shaham
Journal:  Cell Death Differ       Date:  2005-02       Impact factor: 15.828

7.  Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans.

Authors:  Takashi Hirose; Brendan D Galvin; H Robert Horvitz
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-16       Impact factor: 11.205

8.  Condensins regulate meiotic DNA break distribution, thus crossover frequency, by controlling chromosome structure.

Authors:  David G Mets; Barbara J Meyer
Journal:  Cell       Date:  2009-09-24       Impact factor: 41.582

9.  Massively parallel sequencing of the polyadenylated transcriptome of C. elegans.

Authors:  Ladeana W Hillier; Valerie Reinke; Philip Green; Martin Hirst; Marco A Marra; Robert H Waterston
Journal:  Genome Res       Date:  2009-01-30       Impact factor: 9.043

Review 10.  egl-1: a key activator of apoptotic cell death in C. elegans.

Authors:  R Nehme; B Conradt
Journal:  Oncogene       Date:  2008-12       Impact factor: 9.867
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  7 in total

1.  Spatiotemporal Gene Expression Analysis of the Caenorhabditis elegans Germline Uncovers a Syncytial Expression Switch.

Authors:  Yonatan B Tzur; Eitan Winter; Jinmin Gao; Tamar Hashimshony; Itai Yanai; Monica P Colaiácovo
Journal:  Genetics       Date:  2018-08-09       Impact factor: 4.562

2.  Progression of Meiosis Is Coordinated by the Level and Location of MAPK Activation Via OGR-2 in Caenorhabditis elegans.

Authors:  Hanna Achache; Lévana Laurent; Yaël Hecker-Mimoun; Hasan Ishtayeh; Yisrael Rappaport; Eitan Kroizer; Monica P Colaiácovo; Yonatan B Tzur
Journal:  Genetics       Date:  2019-03-13       Impact factor: 4.562

3.  Functional recovery of the germ line following splicing collapse.

Authors:  Wei Cao; Christopher Tran; Stuart K Archer; Sandeep Gopal; Roger Pocock
Journal:  Cell Death Differ       Date:  2021-10-18       Impact factor: 12.067

4.  Maintenance of Genome Integrity by Mi2 Homologs CHD-3 and LET-418 in Caenorhabditis elegans.

Authors:  Carolyn A Turcotte; Solomon A Sloat; Julia A Rigothi; Erika Rosenkranse; Alexandra L Northrup; Nicolas P Andrews; Paula M Checchi
Journal:  Genetics       Date:  2018-01-16       Impact factor: 4.562

5.  Systematic analysis of long intergenic non-coding RNAs in C. elegans germline uncovers roles in somatic growth.

Authors:  Hasan Ishtayeh; Hanna Achache; Eitan Kroizer; Yisrael Rappaport; Eyal Itskovits; Hila Gingold; Corinne Best; Oded Rechavi; Yonatan B Tzur
Journal:  RNA Biol       Date:  2020-09-05       Impact factor: 4.652

6.  The Adverse Effects of Triptolide on the Reproductive System of Caenorhabditis elegans: Oogenesis Impairment and Decreased Oocyte Quality.

Authors:  Qinli Ruan; Yun Xu; Rui Xu; Jiaying Wang; Yongqing Hua; Meng Wang; Jinao Duan
Journal:  Int J Mol Sci       Date:  2017-02-21       Impact factor: 5.923

Review 7.  Phospho-Regulation of Meiotic Prophase.

Authors:  Funda M Kar; Andreas Hochwagen
Journal:  Front Cell Dev Biol       Date:  2021-04-13
  7 in total

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