Literature DB >> 2521677

Adenovirus E1A represses transcription of the cellular JE gene.

H T Timmers1, H van Dam, G J Pronk, J L Bos, A J Van der Eb.   

Abstract

The expression of the growth factor-inducible JE gene was severely reduced in cells expressing region E1A of human adenoviruses. This reduction was not caused by a decreased stability of JE mRNA but by a reduced transcription rate as determined by run-on transcription experiments. Nevertheless, JE mRNA could still be induced by growth factors, suggesting that intracellular signaling is not blocked but rather that the basal level of JE transcription is repressed by E1A.

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Year:  1989        PMID： 2521677      PMCID： PMC247854     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  29 in total

1.  Association of adenovirus early-region 1A proteins with cellular polypeptides.

Authors:  E Harlow; P Whyte; B R Franza; C Schley
Journal:  Mol Cell Biol       Date:  1986-05       Impact factor: 4.272

2.  Platelet-derived growth factor-inducible genes respond differentially to at least two distinct intracellular second messengers.

Authors:  D J Hall; C D Stiles
Journal:  J Biol Chem       Date:  1987-11-05       Impact factor: 5.157

3.  Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen.

Authors:  P J Mitchell; C Wang; R Tjian
Journal:  Cell       Date:  1987-09-11       Impact factor: 41.582

Review 4.  Adenovirus promoters and E1A transactivation.

Authors:  A J Berk
Journal:  Annu Rev Genet       Date:  1986       Impact factor: 16.830

5.  Functions of adenovirus E1A.

Authors:  A J Berk
Journal:  Cancer Surv       Date:  1986

6.  Post-transcriptional control of class I MHC mRNA expression in adenovirus 12-transformed cells.

Authors:  R T Vaessen; A Houweling; A J van der Eb
Journal:  Science       Date:  1987-03-20       Impact factor: 47.728

7.  A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides.

Authors:  M Verlaan-de Vries; M E Bogaard; H van den Elst; J H van Boom; A J van der Eb; J L Bos
Journal:  Gene       Date:  1986       Impact factor: 3.688

8.  A TATA box implicated in E1A transcriptional activation of a simple adenovirus 2 promoter.

Authors:  L Wu; D S Rosser; M C Schmidt; A Berk
Journal:  Nature       Date:  1987 Apr 2-8       Impact factor: 49.962

9.  Activation of adenovirus 5 E1A transcription by region E1B in transformed primary rat cells.

Authors:  A G Jochemsen; L T Peltenburg; M F te Pas; C M de Wit; J L Bos; A J van der Eb
Journal:  EMBO J       Date:  1987-11       Impact factor: 11.598

10.  Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation.

Authors:  J F Schneider; F Fisher; C R Goding; N C Jones
Journal:  EMBO J       Date:  1987-07       Impact factor: 11.598
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  15 in total

1.  Downregulation of JE and KC genes by glucocorticoids does not prevent the G0----G1 transition in BALB/3T3 cells.

Authors:  L E Rameh; M C Armelin
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

2.  DNA-binding properties of the E1A-associated 300-kilodalton protein.

Authors:  Y Rikitake; E Moran
Journal:  Mol Cell Biol       Date:  1992-06       Impact factor: 4.272

3.  Analysis of the rat JE gene promoter identifies an AP-1 binding site essential for basal expression but not for TPA induction.

Authors:  H T Timmers; G J Pronk; J L Bos; A J van der Eb
Journal:  Nucleic Acids Res       Date:  1990-01-11       Impact factor: 16.971

4.  The v-src inducible gene 9E3/pCEF4 is regulated by both its promoter upstream sequence and its 3' untranslated region.

Authors:  G A Blobel; H Hanafusa
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-15       Impact factor: 11.205

5.  Maintenance of cellular proliferation by adenovirus early region 1A in fibroblasts conditionally immortalized by using simian virus 40 large T antigen requires conserved region 1.

Authors:  T E Riley; A Follin; N C Jones; P S Jat
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

6.  Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family.

Authors:  H van Dam; R Offringa; I Meijer; B Stein; A M Smits; P Herrlich; J L Bos; A J van der Eb
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

7.  Expression of the type I DNA topoisomerase gene in adenovirus-5 infected human cells.

Authors:  H Romig; A Richter
Journal:  Nucleic Acids Res       Date:  1990-02-25       Impact factor: 16.971

8.  Activation in vitro of RNA polymerase II and III directed transcription by baculovirus produced E1A protein.

Authors:  G Patel; N C Jones
Journal:  Nucleic Acids Res       Date:  1990-05-25       Impact factor: 16.971

9.  The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains.

Authors:  J C Dorsman; B M Hagmeyer; J Veenstra; P Elfferich; N Nabben; A Zantema; A J van der Eb
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

10.  Inhibition of chemokine expression by adenovirus early region three (E3) genes.

Authors:  Alexander M Lesokhin; Fernando Delgado-Lopez; Marshall S Horwitz
Journal:  J Virol       Date:  2002-08       Impact factor: 5.103
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